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Proteins/UNIPROT:Q5T0W9

SACK1B

Protein·UNIPROT:Q5T0W9

Open in the graph

Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades..

Function from UniProtKB (Q5T0W9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

11 statements

11 statements · 3 reference databases · Subject: SACK1B · Sources: gene ontology, Hetionet, Reactome

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LCE3A covaries with SACK1BProteinHetionet hetionet:covaries:222584-353142Inferred only
SACK1B participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
SACK1B participates in RND1 GTPase cyclePathwayReactome R-HSA-9696273Inferred only
SACK1B participates in RND2 GTPase cyclePathwayReactome R-HSA-9696270Inferred only
SACK1B participates in RND3 GTPase cyclePathwayReactome R-HSA-9696264Inferred only
SACK1B participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
SACK1B participates in Signaling by EGFRPathwayReactome R-HSA-177929Inferred only
SACK1B participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
SACK1B participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
SACK1B participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
SACK1B regulates positive regulation of epidermal growth factor receptor signaling pathwayBiological processgene ontology Q5T0W9|GO:0045742Inferred only

Other names

4 names

Resolves to: SACK1B

Also called: C6orf143FAM83BProtein FAM83BScaffolding CK1 anchoring protein B

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