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Proteins/UNIPROT:Q8WXD0

RXFP2

Protein·UNIPROT:Q8WXD0

Open in the graph

Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).

Function from UniProtKB (Q8WXD0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

13 statements

13 statements · 4 reference databases · Subject: RXFP2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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INSL3 interacts with RXFP2ProteinHetionet hetionet:interacts:122042-3640Inferred only
RLN2 interacts with RXFP2ProteinHetionet hetionet:interacts:122042-6019Inferred only
RXFP2 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
RXFP2 participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
RXFP2 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
RXFP2 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
RXFP2 participates in Myometrial relaxation and contraction pathwaysPathwayWikiPathways WP289Inferred only
RXFP2 participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only
RXFP2 participates in Relaxin receptorsPathwayReactome R-HSA-444821Inferred only
RXFP2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
RXFP2 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
RXFP2 regulates negative regulation of apoptotic processBiological processgene ontology Q8WXD0|GO:0043066Inferred only

Show the remaining 1

RXFP2 regulates negative regulation of cell population proliferationBiological processgene ontology Q8WXD0|GO:0008285Inferred only

Other names

7 names

Resolves to: RXFP2

Also called: G protein-coupled receptor 106G protein-coupled receptor affecting testicular descentGPR106GREATLeucine-rich repeat-containing G protein-coupled receptor 8LGR8Relaxin family peptide receptor 2

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