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Proteins/UNIPROT:P51460

INSL3

Protein·UNIPROT:P51460

Open in the graph

Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.

Function from UniProtKB (P51460), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

cryptorchidism has a germline basis in INSL3DiseaseGenCC HGNC:6086|MONDO:0009047Inferred only

Statements

15 statements

15 statements · 4 reference databases · Subject: INSL3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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INSL3 covaries with IARS2ProteinHetionet hetionet:covaries:3640-55699Inferred only
INSL3 covaries with MGST1ProteinHetionet hetionet:covaries:3640-4257Inferred only
INSL3 interacts with RXFP2ProteinHetionet hetionet:interacts:122042-3640Inferred only
INSL3 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
INSL3 participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
INSL3 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
INSL3 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
INSL3 participates in Mammalian disorder of sexual developmentPathwayWikiPathways WP4842Inferred only
INSL3 participates in MET in type 1 papillary renal cell carcinomaPathwayWikiPathways WP4205Inferred only
INSL3 participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only
INSL3 participates in Relaxin receptorsPathwayReactome R-HSA-444821Inferred only
INSL3 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only

Show the remaining 3

INSL3 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
INSL3 regulates positive regulation of epithelial cell migrationBiological processgene ontology P51460|GO:0010634Inferred only
INSL3 regulates positive regulation of wound healingBiological processgene ontology P51460|GO:0090303Inferred only

Other names

6 names

Resolves to: INSL3

Also called: [Cleaved into: Insulin-like 3 B chain; Insulin-like 3 A chain]Ley-I-LLeydig insulin-like peptideRelaxin-like factorRLFRLNL

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