Proteins/UNIPROT:Q2I0M5

RSPO4

ProteinUNIPROT:Q2I0M5

Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway..

Function from UniProtKB (Q2I0M5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

nonsyndromic congenital nail disorder 4 has a germline basis in RSPO4DiseaseGenCC HGNC:16175|MONDO:0008798Inferred only

Statements

26 statements

26 statements · 3 reference databases · Subject: RSPO4 · Sources: gene ontology, Hetionet, Reactome

Order

RSPO4 covaries with AFF3ProteinHetionet hetionet:covaries:343637-3899Inferred only
RSPO4 covaries with CDKN3ProteinHetionet hetionet:covaries:1033-343637Inferred only
RSPO4 covaries with CORO1AProteinHetionet hetionet:covaries:11151-343637Inferred only
DIS3L covaries with RSPO4ProteinHetionet hetionet:covaries:115752-343637Inferred only
DUSP15 covaries with RSPO4ProteinHetionet hetionet:covaries:128853-343637Inferred only
RSPO4 covaries with EHD2ProteinHetionet hetionet:covaries:30846-343637Inferred only
H2AC11; H2AC13; H2AC15; H2AC16; H2AC17 covaries with RSPO4ProteinHetionet hetionet:covaries:343637-8330Inferred only
RSPO4 covaries with ISYNA1ProteinHetionet hetionet:covaries:343637-51477Inferred only
RSPO4 covaries with NHERF2ProteinHetionet hetionet:covaries:343637-9351Inferred only
RSPO4 covaries with NPAS1ProteinHetionet hetionet:covaries:343637-4861Inferred only
OR4D6 covaries with RSPO4ProteinHetionet hetionet:covaries:219983-343637Inferred only
RSPO4 covaries with PKDCCProteinHetionet hetionet:covaries:343637-91461Inferred only

Show the remaining 14

RSPO4 covaries with PPP1R9BProteinHetionet hetionet:covaries:343637-84687Inferred only
PRDM12 covaries with RSPO4ProteinHetionet hetionet:covaries:343637-59335Inferred only
RAB43 covaries with RSPO4ProteinHetionet hetionet:covaries:339122-343637Inferred only
RSPO4 covaries with RHBDL1ProteinHetionet hetionet:covaries:343637-9028Inferred only
RNF148 covaries with RSPO4ProteinHetionet hetionet:covaries:343637-378925Inferred only
RSPO4 covaries with RPS6KA4ProteinHetionet hetionet:covaries:343637-8986Inferred only
SAMD5 covaries with RSPO4ProteinHetionet hetionet:covaries:343637-389432Inferred only
RSPO4 covaries with TRIM11ProteinHetionet hetionet:covaries:343637-81559Inferred only
RSPO4 participates in Regulation of FZD by ubiquitinationPathwayReactome R-HSA-4641263Inferred only
RSPO4 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
RSPO4 participates in Signaling by WNTPathwayReactome R-HSA-195721Inferred only
RSPO4 participates in TCF dependent signaling in response to WNTPathwayReactome R-HSA-201681Inferred only
RSPO4 regulates positive regulation of canonical Wnt signaling pathwayBiological processgene ontology Q2I0M5|GO:0090263Inferred only
RSPO4 regulates positive regulation of Wnt signaling pathwayBiological processgene ontology Q2I0M5|GO:0030177Inferred only

Other names

3 names

Resolves to: RSPO4

Also called: C20orf182hRspo4Roof plate-specific spondin-4

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