Proteins/UNIPROT:Q99742

NPAS1

ProteinUNIPROT:Q99742

May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level (By similarity). Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH (By similarity)..

Function from UniProtKB (Q99742), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

11 statements

11 statements · 2 reference databases · Subject: NPAS1 · Sources: gene ontology, Hetionet

Order

NPAS1 covaries with EGLN3ProteinHetionet hetionet:covaries:112399-4861Inferred only
KLF4 covaries with NPAS1ProteinHetionet hetionet:covaries:4861-9314Inferred only
LONRF1 covaries with NPAS1ProteinHetionet hetionet:covaries:4861-91694Inferred only
RSPO4 covaries with NPAS1ProteinHetionet hetionet:covaries:343637-4861Inferred only
NPAS1 covaries with S100PBPProteinHetionet hetionet:covaries:4861-64766Inferred only
NPAS1 covaries with SH2D3AProteinHetionet hetionet:covaries:10045-4861Inferred only
TRPT1 covaries with NPAS1ProteinHetionet hetionet:covaries:4861-83707Inferred only
TSEN34 covaries with NPAS1ProteinHetionet hetionet:covaries:4861-79042Inferred only
NPAS1 covaries with ZNF692ProteinHetionet hetionet:covaries:4861-55657Inferred only
NPAS1 regulates negative regulation of DNA-templated transcriptionBiological processgene ontology Q99742|GO:0045892Inferred only
NPAS1 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q99742|GO:0006357Inferred only

Other names

8 names

Resolves to: NPAS1

Also called: Basic-helix-loop-helix-PAS protein MOP5BHLHE11Class E basic helix-loop-helix protein 11Member of PAS protein 5MOP5Neuronal PAS1PAS domain-containing protein 5PASD5

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