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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q8TC41

RNF217

Protein·UNIPROT:Q8TC41

Open in the graph

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the degradation of the iron exporter ferroportin/SLC40A1 and thus regulates iron homeostasis..

Function from UniProtKB (Q8TC41), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

6 statements

6 statements · 2 reference databases · Subject: RNF217 · Sources: Hetionet, Reactome

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RNF217 covaries with BTG4ProteinHetionet hetionet:covaries:154214-54766Inferred only
UBC interacts with RNF217ProteinHetionet hetionet:interacts:154214-7316Inferred only
RNF217 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
RNF217 participates in Antigen processing: Ubiquitination & Proteasome degradationPathwayReactome R-HSA-983168Inferred only
RNF217 participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only
RNF217 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only

Reactions

1 reaction

MAM00204c+ATP+MAM03105cMAM00214c+AMP+diphosphate(3-)
Catalysed by RNF40 & RNF20 or SAE1 & UBA2 or RING1 & RNF2 or HECW1 or MYCBP2 or MYLIP or UBE3C or RNF216 or UBR7 or RNF14 or UBR2

Other names

6 names

Resolves to: RNF217

Also called: C6orf172IBR domain-containing protein 1IBRDC1Opposite STLOSTLRING finger protein 217

← Every protein Find it in the graph →

or UBA6

and 160 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 2.3.2.23, 2.3.2.27, 6.2.1.45cytosol

Human-GEM MAR09491CC BY 4.0Reference data