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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q8NC42

RNF149

Protein·UNIPROT:Q8NC42

Open in the graph

E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation..

Function from UniProtKB (Q8NC42), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

4 statements

4 statements · 1 reference database · Subject: RNF149 · Sources: Hetionet

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RNF149 covaries with PLPPR3ProteinHetionet hetionet:covaries:284996-79948Inferred only
SPON2 covaries with RNF149ProteinHetionet hetionet:covaries:10417-284996Inferred only
TCEAL3 covaries with RNF149ProteinHetionet hetionet:covaries:284996-85012Inferred only
UBC interacts with RNF149ProteinHetionet hetionet:interacts:284996-7316Inferred only

Reactions

1 reaction

MAM00204c+ATP+MAM03105cMAM00214c+AMP+diphosphate(3-)
Catalysed by RNF40 & RNF20 or SAE1 & UBA2 or RING1 & RNF2 or HECW1 or MYCBP2 or MYLIP or UBE3C or RNF216 or UBR7 or RNF14 or UBR2

Other names

4 names

Resolves to: RNF149

Also called: DNA polymerase-transactivated protein 2DNAPTP2RING finger protein 149RING-type E3 ubiquitin transferase RNF149

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or UBA6

and 160 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 2.3.2.23, 2.3.2.27, 6.2.1.45cytosol

Human-GEM MAR09491CC BY 4.0Reference data