Proteins/UNIPROT:O60930

RNASEH1

ProteinUNIPROT:O60930

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II..

Function from UniProtKB (O60930), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy has a germline basis in RNASEH1DiseaseGenCC HGNC:18466|MONDO:0018002Inferred only
progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2 has a germline basis in RNASEH1DiseaseGenCC HGNC:18466|MONDO:0014656Inferred only

Statements

6 statements

6 statements · 3 reference databases · Subject: RNASEH1 · Sources: Hetionet, Reactome, UniProt

Order

ABCA13 covaries with RNASEH1ProteinHetionet hetionet:covaries:154664-246243Inferred only
TM9SF1 interacts with RNASEH1ProteinHetionet hetionet:interacts:10548-246243Inferred only
RNASEH1 participates in DNA ReplicationPathwayReactome R-HSA-69306Inferred only
RNASEH1 participates in Strand-asynchronous mitochondrial DNA replicationPathwayReactome R-HSA-9913635Inferred only
DMTF1 increases the expression of RNASEH1ProteinHetionet hetionet:regulates:9988-246243Inferred only
RNASEH1 requires the cofactor magnesium(2+)CompoundUniProt O60930Inferred only

Other names

3 names

Resolves to: RNASEH1

Also called: Ribonuclease H type IIRNase H1RNH1

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