Proteins/UNIPROT:O43374

RASA4

ProteinUNIPROT:O43374

Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis..

Function from UniProtKB (O43374), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

17 statements

17 statements · 5 reference databases · Subject: RASA4 · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways

Order

RASA4 interacts with APMAPProteinHetionet hetionet:interacts:10156-57136Inferred only
RASA4 interacts with CRAMP1ProteinHetionet hetionet:interacts:10156-57585Inferred only
ERBB3 interacts with RASA4ProteinHetionet hetionet:interacts:10156-2065Inferred only
RASA4 interacts with JPT2ProteinHetionet hetionet:interacts:10156-90861Inferred only
OVGP1 interacts with RASA4ProteinHetionet hetionet:interacts:10156-5016Inferred only
UBC interacts with RASA4ProteinHetionet hetionet:interacts:10156-7316Inferred only
RASA4 participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
RASA4 participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
RASA4 participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
RASA4 participates in Ras signalingPathwayWikiPathways WP4223Inferred only
RASA4 participates in Regulation of RAS by GAPsPathwayReactome R-HSA-5658442Inferred only
RASA4 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only

Show the remaining 5

RASA4 regulates negative regulation of GTPase activityBiological processgene ontology O43374|GO:0034260Inferred only
RASA4 regulates negative regulation of Ras protein signal transductionBiological processgene ontology O43374|GO:0046580Inferred only
RASA4 regulates regulation of intracellular signal transductionBiological processgene ontology O43374|GO:1902531Inferred only
C1S increases the expression of RASA4ProteinHetionet hetionet:regulates:716-10156Inferred only
RASA4 requires the cofactor Ca(2+)CompoundUniProt O43374Inferred only

Other names

6 names

Resolves to: RASA4

Also called: Calcium-promoted Ras inactivatorCAPRIGAPLKIAA0538Ras p21 protein activator 4RasGAP-activating-like protein 2

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