Proteins/UNIPROT:O15091

PRORP

ProteinUNIPROT:O15091

Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends..

Function from UniProtKB (O15091), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

combined oxidative phosphorylation deficiency 54 has a germline basis in PRORPDiseaseGenCC HGNC:19958|MONDO:0030543Inferred only
mitochondrial disease has a germline basis in PRORPDiseaseGenCC HGNC:19958|MONDO:0044970Inferred only

Statements

27 statements

27 statements · 4 reference databases · Subject: PRORP · Sources: Hetionet, Reactome, UniProt, WikiPathways

Order

UBC interacts with PRORPProteinHetionet hetionet:interacts:7316-9692Inferred only
PRORP participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
PRORP participates in Primary ovarian insufficiencyPathwayWikiPathways WP5461Inferred only
PRORP participates in rRNA processingPathwayReactome R-HSA-72312Inferred only
PRORP participates in rRNA processing in the mitochondrionPathwayReactome R-HSA-8868766Inferred only
PRORP participates in tRNA modification in the mitochondrionPathwayReactome R-HSA-6787450Inferred only
PRORP participates in tRNA processingPathwayReactome R-HSA-72306Inferred only
PRORP participates in tRNA processing in the mitochondrionPathwayReactome R-HSA-6785470Inferred only
ACAT2 decreases the expression of PRORPProteinHetionet hetionet:regulates:39-9692Inferred only
ATP1B1 decreases the expression of PRORPProteinHetionet hetionet:regulates:481-9692Inferred only
ATP6V0C decreases the expression of PRORPProteinHetionet hetionet:regulates:527-9692Inferred only
COPZ1 decreases the expression of PRORPProteinHetionet hetionet:regulates:22818-9692Inferred only

Show the remaining 15

DIDO1 decreases the expression of PRORPProteinHetionet hetionet:regulates:11083-9692Inferred only
EPHB4 decreases the expression of PRORPProteinHetionet hetionet:regulates:2050-9692Inferred only
FOXO4 increases the expression of PRORPProteinHetionet hetionet:regulates:4303-9692Inferred only
HSF1 increases the expression of PRORPProteinHetionet hetionet:regulates:3297-9692Inferred only
IQGAP1 decreases the expression of PRORPProteinHetionet hetionet:regulates:8826-9692Inferred only
ITGAV decreases the expression of PRORPProteinHetionet hetionet:regulates:3685-9692Inferred only
RARA decreases the expression of PRORPProteinHetionet hetionet:regulates:5914-9692Inferred only
RXYLT1 decreases the expression of PRORPProteinHetionet hetionet:regulates:10329-9692Inferred only
SNRPD1 decreases the expression of PRORPProteinHetionet hetionet:regulates:6632-9692Inferred only
SRC decreases the expression of PRORPProteinHetionet hetionet:regulates:6714-9692Inferred only
SRRT decreases the expression of PRORPProteinHetionet hetionet:regulates:51593-9692Inferred only
XBP1 decreases the expression of PRORPProteinHetionet hetionet:regulates:7494-9692Inferred only
ZFX decreases the expression of PRORPProteinHetionet hetionet:regulates:7543-9692Inferred only
PRORP requires the cofactor magnesium(2+)CompoundUniProt O15091Inferred only
PRORP requires the cofactor Mn(2+)CompoundUniProt O15091Inferred only

Other names

6 names

Resolves to: PRORP

Also called: KIAA0391Mitochondrial ribonuclease P protein 3Mitochondrial RNase P protein 3MRPP3only RNase P catalytic subunitProtein only RNase P catalytic subunit

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