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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:O75360

PROP1

Protein·UNIPROT:O75360

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Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.

Function from UniProtKB (O75360), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

4 rows

combined pituitary hormone deficiencies, genetic form has a germline basis in PROP1DiseaseGenCC HGNC:9455|MONDO:0013099Inferred only
hypothyroidism due to deficient transcription factors involved in pituitary development or function has a germline basis in PROP1DiseaseGenCC HGNC:9455|MONDO:0016411Inferred only
panhypopituitarism has a germline basis in PROP1DiseaseGenCC HGNC:9455|MONDO:0019591Inferred only
pituitary hormone deficiency, combined, 2 has a germline basis in PROP1DiseaseGenCC HGNC:9455|MONDO:0009878Inferred only

Statements

5 statements

5 statements · 2 reference databases · Subject: PROP1 · Sources: gene ontology, Hetionet

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CTNNB1 interacts with PROP1ProteinHetionet hetionet:interacts:1499-5626Inferred only
PROP1 interacts with HESX1ProteinHetionet hetionet:interacts:5626-8820Inferred only
PITX2 interacts with PROP1ProteinHetionet hetionet:interacts:5308-5626Inferred only
PROP1 interacts with TLE1ProteinHetionet hetionet:interacts:5626-7088Inferred only
PROP1 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology O75360|GO:0006357Inferred only

Other names

2 names

Resolves to: PROP1

Also called: Pituitary-specific homeodomain factorPROP-1

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