panhypopituitarism
MONDO:0019591Mondo
Findings
No curated finding names panhypopituitarism yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Insufficient production of all the anterior pituitary hormones.
Definition from the Mondo Disease Ontology (MONDO:0019591), read 2026-09-29. CC BY 4.0.
Features
27 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- HypopituitarismHPOHP:0040075
- Obligate (100% of cases)
- Abnormal prolactin levelHPOHP:0040086
- Frequent (30% to 79% of cases)
- Abnormality of secondary sexual hairHPOHP:0009888
- Frequent (30% to 79% of cases)
- AmenorrheaHPOHP:0000141
- Frequent (30% to 79% of cases)
- Anterior pituitary hypoplasiaHPOHP:0010627
- Frequent (30% to 79% of cases)
- Aplasia/Hypoplasia of the breastsHPOHP:0010311
- Frequent (30% to 79% of cases)
- Decreased circulating ACTH concentrationHPOHP:0002920
- Frequent (30% to 79% of cases)
- Decreased response to growth hormone stimulation testHPOHP:0000824
- Frequent (30% to 79% of cases)
- Decreased testicular sizeHPOHP:0008734
- Frequent (30% to 79% of cases)
- Depressed nasal ridgeHPOHP:0000457
- Frequent (30% to 79% of cases)
- FatigueHPOHP:0012378
- Frequent (30% to 79% of cases)
- Growth delayHPOHP:0001510
- Frequent (30% to 79% of cases)
Show the remaining 15
- HypoglycemiaHPOHP:0001943
- Frequent (30% to 79% of cases)
- Hypogonadotropic hypogonadismHPOHP:0000044
- Frequent (30% to 79% of cases)
- HypotensionHPOHP:0002615
- Frequent (30% to 79% of cases)
- InfertilityHPOHP:0000789
- Frequent (30% to 79% of cases)
- Pituitary hypothyroidismHPOHP:0008245
- Frequent (30% to 79% of cases)
- Short statureHPOHP:0004322
- Frequent (30% to 79% of cases)
Genes
2 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
- Narrower terms (2)
Other names
1 name
Resolves to: panhypopituitarism
- Also called
- complete hypopituitarism