Proteins/UNIPROT:O43490

PROM1

ProteinUNIPROT:O43490

May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner..

Function from UniProtKB (O43490), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

8 rows

cone-rod dystrophy has a germline basis in PROM1DiseaseGenCC HGNC:9454|MONDO:0015993Inferred only
cone-rod dystrophy 12 has a germline basis in PROM1DiseaseGenCC HGNC:9454|MONDO:0012983Inferred only
PROM1-related dominant retinopathy has a germline basis in PROM1DiseaseGenCC HGNC:9454|MONDO:1040053Inferred only
PROM1-related recessive retinopathy has a germline basis in PROM1DiseaseGenCC HGNC:9454|MONDO:1040052Inferred only
retinal macular dystrophy type 2 has a germline basis in PROM1DiseaseGenCC HGNC:9454|MONDO:0011957Inferred only
retinitis pigmentosa has a germline basis in PROM1DiseaseGenCC HGNC:9454|MONDO:0019200Inferred only
retinitis pigmentosa 41 has a germline basis in PROM1DiseaseGenCC HGNC:9454|MONDO:0012796Inferred only
Stargardt disease has a germline basis in PROM1DiseaseGenCC HGNC:9454|MONDO:0019353Inferred only

Statements

15 statements

15 statements · 4 reference databases · Subject: PROM1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ACTB interacts with PROM1ProteinHetionet hetionet:interacts:60-8842Inferred only
PROM1 interacts with CDHR1ProteinHetionet hetionet:interacts:8842-92211Inferred only
PROM1 interacts with PLEKHA5ProteinHetionet hetionet:interacts:54477-8842Inferred only
PROM1 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
PROM1 participates in Developmental Cell LineagesPathwayReactome R-HSA-9734767Inferred only
PROM1 participates in Developmental Cell Lineages of the Exocrine PancreasPathwayReactome R-HSA-9820448Inferred only
PROM1 participates in Developmental Lineage of Pancreatic Ductal CellsPathwayReactome R-HSA-9925563Inferred only
PROM1 participates in Developmental Lineage of Pancreatic Endocrine Mid Progenitor CellsPathwayReactome R-HSA-9981148Inferred only
PROM1 participates in Extracellular vesicle mediated signaling in recipient cellsPathwayWikiPathways WP2870Inferred only
PROM1 participates in Hair follicle development cytodifferentiation stage 3 of 3PathwayWikiPathways WP2840Inferred only
PROM1 participates in HDAC6 interactions in the central nervous systemPathwayWikiPathways WP5426Inferred only
PROM1 regulates positive regulation of nephron tubule epithelial cell differentiationBiological processgene ontology O43490|GO:2000768Inferred only

Show the remaining 3

CYP51A1 decreases the expression of PROM1ProteinHetionet hetionet:regulates:1595-8842Inferred only
PHF2 decreases the expression of PROM1ProteinHetionet hetionet:regulates:5253-8842Inferred only
PTEN increases the expression of PROM1ProteinHetionet hetionet:regulates:5728-8842Inferred only

Other names

4 names

Resolves to: PROM1

Also called: Antigen AC133CD antigen CD133Prominin-like protein 1PROML1

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