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Proteins/UNIPROT:Q9P2J9
Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA (By similarity). Acts as a crucial regulator of T cell metabolism and function, with a particular focus on T-helper Th17 (By similarity)..
Function from UniProtKB (Q9P2J9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
10 statements
10 statements · 4 reference databases · Subject: PDP2 · Sources: Hetionet, Reactome, UniProt, WikiPathways
2 reactions
MAM00220c+waterMAM00219c+phosphate(3-)
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.43cytosol
Human-GEM MAR09516CC BY 4.0Reference data
O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]+waterL-seryl-[pyruvate dehydrogenase E1 alpha subunit]+hydrogenphosphate
4 names
Resolves to: PDP2
Rhea RHEA:12669CC BY 4.0Reference data