Proteins/UNIPROT:Q13416

ORC2

ProteinUNIPROT:Q13416

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3..

Function from UniProtKB (Q13416), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

64 statements

64 statements · 4 reference databases · Subject: ORC2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

CASP14 covaries with ORC2ProteinHetionet hetionet:covaries:23581-4999Inferred only
CHAMP1 covaries with ORC2ProteinHetionet hetionet:covaries:283489-4999Inferred only
GPR174 covaries with ORC2ProteinHetionet hetionet:covaries:4999-84636Inferred only
ORC2 interacts with CDC45ProteinHetionet hetionet:interacts:4999-8318Inferred only
CDC5L interacts with ORC2ProteinHetionet hetionet:interacts:4999-988Inferred only
CDC6 interacts with ORC2ProteinHetionet hetionet:interacts:4999-990Inferred only
CDK2 interacts with ORC2ProteinHetionet hetionet:interacts:1017-4999Inferred only
ORC2 interacts with CDT1ProteinHetionet hetionet:interacts:4999-81620Inferred only
ORC2 interacts with DBF4ProteinHetionet hetionet:interacts:10926-4999Inferred only
ORC2 interacts with HAUS1ProteinHetionet hetionet:interacts:115106-4999Inferred only
HMGA1 interacts with ORC2ProteinHetionet hetionet:interacts:3159-4999Inferred only
ORC2 interacts with KAT7ProteinHetionet hetionet:interacts:11143-4999Inferred only

Show the remaining 52

ORC2 interacts with LRWD1ProteinHetionet hetionet:interacts:222229-4999Inferred only
ORC2 interacts with MCM10ProteinHetionet hetionet:interacts:4999-55388Inferred only
MCM2 interacts with ORC2ProteinHetionet hetionet:interacts:4171-4999Inferred only
MCM4 interacts with ORC2ProteinHetionet hetionet:interacts:4173-4999Inferred only
MCM5 interacts with ORC2ProteinHetionet hetionet:interacts:4174-4999Inferred only
MCM6 interacts with ORC2ProteinHetionet hetionet:interacts:4175-4999Inferred only
MCM7 interacts with ORC2ProteinHetionet hetionet:interacts:4176-4999Inferred only
ORC2 interacts with MCM8ProteinHetionet hetionet:interacts:4999-84515Inferred only
ORC1 interacts with ORC2ProteinHetionet hetionet:interacts:4998-4999Inferred only
ORC2 interacts with ORC3ProteinHetionet hetionet:interacts:23595-4999Inferred only
ORC2 interacts with ORC4ProteinHetionet hetionet:interacts:4999-5000Inferred only
ORC2 interacts with ORC5ProteinHetionet hetionet:interacts:4999-5001Inferred only
ORC2 interacts with ORC6ProteinHetionet hetionet:interacts:23594-4999Inferred only
ORC2 interacts with RNF8ProteinHetionet hetionet:interacts:4999-9025Inferred only
ORC2 interacts with RPA1ProteinHetionet hetionet:interacts:4999-6117Inferred only
ORC2 interacts with RPA2ProteinHetionet hetionet:interacts:4999-6118Inferred only
ORC2 interacts with SUMO2ProteinHetionet hetionet:interacts:4999-6613Inferred only
ORC2 interacts with TERF1ProteinHetionet hetionet:interacts:4999-7013Inferred only
ORC2 interacts with TERF2ProteinHetionet hetionet:interacts:4999-7014Inferred only
ORC2 interacts with TERF2IPProteinHetionet hetionet:interacts:4999-54386Inferred only
ORC2 interacts with UBCProteinHetionet hetionet:interacts:4999-7316Inferred only
ORC2 interacts with XRCC5ProteinHetionet hetionet:interacts:4999-7520Inferred only
ORC2 participates in Activation of ATR in response to replication stressPathwayReactome R-HSA-176187Inferred only
ORC2 participates in Activation of the pre-replicative complexPathwayReactome R-HSA-68962Inferred only
ORC2 participates in Assembly of the ORC complex at the origin of replicationPathwayReactome R-HSA-68616Inferred only
ORC2 participates in Assembly of the pre-replicative complexPathwayReactome R-HSA-68867Inferred only
ORC2 participates in CDC6 association with the ORC:origin complexPathwayReactome R-HSA-68689Inferred only
ORC2 participates in Cell cyclePathwayWikiPathways WP179Inferred only
ORC2 participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
ORC2 participates in Cell Cycle CheckpointsPathwayReactome R-HSA-69620Inferred only
ORC2 participates in Cell Cycle, MitoticPathwayReactome R-HSA-69278Inferred only
ORC2 participates in DNA replicationPathwayWikiPathways WP466Inferred only
ORC2 participates in DNA ReplicationPathwayReactome R-HSA-69306Inferred only
ORC2 participates in DNA Replication Pre-InitiationPathwayReactome R-HSA-69002Inferred only
ORC2 participates in E2F mediated regulation of DNA replicationPathwayReactome R-HSA-113510Inferred only
ORC2 participates in E2F-enabled inhibition of pre-replication complex formationPathwayReactome R-HSA-113507Inferred only
ORC2 participates in G1 to S cell cycle controlPathwayWikiPathways WP45Inferred only
ORC2 participates in G1/S TransitionPathwayReactome R-HSA-69206Inferred only
ORC2 participates in G2/M CheckpointsPathwayReactome R-HSA-69481Inferred only
ORC2 participates in Mitotic G1 phase and G1/S transitionPathwayReactome R-HSA-453279Inferred only
ORC2 participates in Orc1 removal from chromatinPathwayReactome R-HSA-68949Inferred only
ORC2 participates in S PhasePathwayReactome R-HSA-69242Inferred only
ORC2 participates in Switching of origins to a post-replicative statePathwayReactome R-HSA-69052Inferred only
ORC2 participates in Synthesis of DNAPathwayReactome R-HSA-69239Inferred only
ORC2 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q13416|GO:0000122Inferred only
EP300 increases the expression of ORC2ProteinHetionet hetionet:regulates:2033-4999Inferred only
NRP1 increases the expression of ORC2ProteinHetionet hetionet:regulates:8829-4999Inferred only
SENP6 decreases the expression of ORC2ProteinHetionet hetionet:regulates:26054-4999Inferred only
SERPINC1 decreases the expression of ORC2ProteinHetionet hetionet:regulates:462-4999Inferred only
SLC25A4 decreases the expression of ORC2ProteinHetionet hetionet:regulates:291-4999Inferred only
TIMP2 increases the expression of ORC2ProteinHetionet hetionet:regulates:7077-4999Inferred only
ZNF768 decreases the expression of ORC2ProteinHetionet hetionet:regulates:79724-4999Inferred only

Other names

2 names

Resolves to: ORC2

Also called: ORC2LOrigin recognition complex subunit 2

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