Proteins/UNIPROT:Q9UFC0

LRWD1

ProteinUNIPROT:Q9UFC0

Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability..

Function from UniProtKB (Q9UFC0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

20 statements

20 statements · 2 reference databases · Subject: LRWD1 · Sources: Hetionet, WikiPathways

Order

LRWD1 covaries with AP5S1ProteinHetionet hetionet:covaries:222229-55317Inferred only
LRWD1 covaries with ARHGEF19ProteinHetionet hetionet:covaries:128272-222229Inferred only
LRWD1 covaries with CCNT1ProteinHetionet hetionet:covaries:222229-904Inferred only
LRWD1 covaries with CEP290ProteinHetionet hetionet:covaries:222229-80184Inferred only
LRWD1 covaries with FCHO1ProteinHetionet hetionet:covaries:222229-23149Inferred only
LRWD1 covaries with HEPACAM2ProteinHetionet hetionet:covaries:222229-253012Inferred only
LRWD1 covaries with IRF1ProteinHetionet hetionet:covaries:222229-3659Inferred only
RAD51D covaries with LRWD1ProteinHetionet hetionet:covaries:222229-5892Inferred only
LRWD1 covaries with SAFBProteinHetionet hetionet:covaries:222229-6294Inferred only
LRWD1 covaries with SLAMF9ProteinHetionet hetionet:covaries:222229-89886Inferred only
TMEM219 covaries with LRWD1ProteinHetionet hetionet:covaries:124446-222229Inferred only
LRWD1 covaries with UBR4ProteinHetionet hetionet:covaries:222229-23352Inferred only

Show the remaining 8

LRWD1 covaries with YLPM1ProteinHetionet hetionet:covaries:222229-56252Inferred only
LRWD1 covaries with ZSCAN30ProteinHetionet hetionet:covaries:100101467-222229Inferred only
LRWD1 covaries with ZWINTProteinHetionet hetionet:covaries:11130-222229Inferred only
CUL4A interacts with LRWD1ProteinHetionet hetionet:interacts:222229-8451Inferred only
DDB1 interacts with LRWD1ProteinHetionet hetionet:interacts:1642-222229Inferred only
ORC2 interacts with LRWD1ProteinHetionet hetionet:interacts:222229-4999Inferred only
UBC interacts with LRWD1ProteinHetionet hetionet:interacts:222229-7316Inferred only
LRWD1 participates in Male infertilityPathwayWikiPathways WP4673Inferred only

Other names

5 names

Resolves to: LRWD1

Also called: CENP-33Centromere protein 33ORC-associated proteinORCAOrigin recognition complex-associated protein

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