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Proteins/UNIPROT:Q9BV86
Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1..
Function from UniProtKB (Q9BV86), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
16 statements
16 statements · 2 reference databases · Subject: NTMT1 · Sources: Bgee, Hetionet
3 reactions
N-terminal L-alanyl-L-prolyl-L-lysyl-[protein]+3S-adenosyl-L-methionineN-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein]+3S-adenosyl-L-homocysteine+3hydron
Catalysed by NTMT1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:54712CC BY 4.0Reference data
N-terminal L-seryl-L-prolyl-L-lysyl-[protein]+3S-adenosyl-L-methionineN-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein]+3S-adenosyl-L-homocysteine+
10 names
Resolves to: NTMT1
Catalysed by NTMT1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:54724CC BY 4.0Reference data
N-terminal L-prolyl-L-prolyl-L-lysyl-[protein]+2S-adenosyl-L-methionineN-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein]+2S-adenosyl-L-homocysteine+2hydron
Catalysed by NTMT1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:54736CC BY 4.0Reference data