Pathway
RHO GTPases Activate NADPH Oxidases
NADPH oxidases (NOX) are membrane-associated enzymatic complexes that use NADPH as an electon donor to reduce oxygen and produce superoxide (O2-) that serves as a secondary messenger.
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NOX2 complex consists of CYBB (NOX2), CYBA (p22phox), NCF1 (p47phox), NCF2 (p67phox) and NCF4 (p40ohox). RAC1:GTP binds NOX2 complex in response to VEGF signaling by directly interracting with CYBB and NCF2, leading to enhancement of VEGF-signaling through VEGF receptor VEGFR2, which plays a role in angiogenesis. RAC2:GTP can also activate the NOX2 complex by binding to CYBB and NCF2, leading to production of superoxide in phagosomes of neutrophils which is necessary fo the microbicidal activity of neutrophils.
NOX1 complex (composed of NOX1, NOXA1, NOXO1 and CYBA) and NOX3 complex (composed of NOX3, CYBA, NCF1 amd NCF2 or NOXA1) can also be activated by binding to RAC1:GTP to produce superoxide.
What the reference databases state
Statements
24 statements
24 statements · 1 reference database · Subject: RHO GTPases Activate NADPH Oxidases · Sources: Reactome
- CYBA participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- CYBB participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- MAPK1 participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- MAPK11 participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- MAPK14 participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- MAPK3 participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- NCF1 participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- NCF2 participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- NCF4 participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- NOX1 participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- NOX3 participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- NOXA1 participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
Show the remaining 12
- NOXO1 participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- PIK3C3 participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- PIK3R4 participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- PIN1 participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- PRKCA participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- PRKCB participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- PRKCD participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- PRKCZ participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- RAC1 participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- RAC2 participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- S100A8 participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only
- S100A9 participates in RHO GTPases Activate NADPH OxidasesProteinReactome R-HSA-5668599Inferred only