Proteins/UNIPROT:A8MTQ0

NOTO

ProteinUNIPROT:A8MTQ0

Transcription regulator acting downstream of both FOXA2 and Brachyury (T) during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate. Activates the transcription of ciliary proteins C11orf97 homolog, FAM183B and SPACA9 in the embryonic ventral node (By similarity)..

Function from UniProtKB (A8MTQ0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

8 statements

8 statements · 3 reference databases · Subject: NOTO · Sources: gene ontology, Hetionet, Reactome

Order

NOTO covaries with DCAF1ProteinHetionet hetionet:covaries:344022-9730Inferred only
NOTO covaries with RNF38ProteinHetionet hetionet:covaries:152006-344022Inferred only
NOTO covaries with SKILProteinHetionet hetionet:covaries:344022-6498Inferred only
NOTO covaries with TMEM170BProteinHetionet hetionet:covaries:100113407-344022Inferred only
NOTO participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
NOTO participates in Formation of axial mesodermPathwayReactome R-HSA-9796292Inferred only
NOTO participates in GastrulationPathwayReactome R-HSA-9758941Inferred only
NOTO regulates regulation of transcription by RNA polymerase IIBiological processgene ontology A8MTQ0|GO:0006357Inferred only

Other names

1 name

Resolves to: NOTO

Also called: Homeobox protein notochord

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