Proteins/UNIPROT:Q9UHF3

NAT8B

ProteinUNIPROT:Q9UHF3N-acetyltransferase 8B

Endoplasmic reticulum (ER)-membrane-bound lysine N-acetyltransferase catalyzing the N6-acetylation of lysine residues in the lumen of the ER in various proteins, including PROM1 and BACE1, using acetyl-CoA as acetyl donor. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1. Acetylates and stabilizes BACE1 immature protein, leading to increased steady-state levels in neurons. By acting on BACE1 expression, may regulate amyloid beta-peptide formation. N(6)-lysine acetylation in ER maintains protein homeostasis and regulates reticulophagy (By similarity)..

Function from UniProtKB (Q9UHF3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

6 statements

6 statements · 2 reference databases · Subject: NAT8B · Sources: gene ontology, Reactome

Order

NAT8B participates in Amyloid fiber formationPathwayReactome R-HSA-977225Inferred only
NAT8B participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
NAT8B regulates negative regulation of apoptotic processBiological processgene ontology Q9UHF3|GO:0043066Inferred only
NAT8B regulates positive regulation of gene expressionBiological processgene ontology Q9UHF3|GO:0010628Inferred only
NAT8B regulates regulation of macroautophagyBiological processgene ontology Q9UHF3|GO:0016241Inferred only
NAT8B regulates regulation of reticulophagyBiological processgene ontology Q9UHF3|GO:0140500Inferred only

Reactions

1 reaction

L-lysyl-[protein]+acetyl-CoAN(6)-acetyl-L-lysyl-[protein]+coenzyme A(4-)+hydron
Catalysed by HAT1 or CLOCK or TAF1 or BLOC1S1 or GTF2B or EP300 or NCOA1 or ESCO2 or ESCO1 or KAT6B or CREBBP or KAT6A and 12 more alternatives
Reaction page

Other names

5 names

Resolves to: NAT8B

Also called: Acetyltransferase 1ATase1Camello-like protein 2CML2Protein-lysine N6-acetyltransferase 8B

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