Proteins/UNIPROT:Q53F39

MPPE1

ProteinUNIPROT:Q53F39Metallophosphoesterase 1

Metallophosphoesterase that catalyzes the removal of a side-chain ethanolamine-phosphate (EtNP) from the second mannose of the GPI-anchor protein intermediate. Participates in the glycan remodeling steps of GPI-anchor maturation to allow an efficient transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi..

Function from UniProtKB (Q53F39), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

8 statements

8 statements · 4 reference databases · Subject: MPPE1 · Sources: Bgee, Hetionet, UniProt, WikiPathways

Order

MPPE1 is expressed in bloodAnatomyBgee ENSG00000154889Inferred only
MPPE1 is expressed in granulocyteCell typeBgee ENSG00000154889Inferred only
UBC interacts with MPPE1ProteinHetionet hetionet:interacts:65258-7316Inferred only
MPPE1 participates in Glycosylphosphatidyl inositol anchor pathwayPathwayWikiPathways WP5505Inferred only
KCNG1 decreases the expression of MPPE1ProteinHetionet hetionet:regulates:3755-65258Inferred only
RNMT decreases the expression of MPPE1ProteinHetionet hetionet:regulates:8731-65258Inferred only
TOP1 decreases the expression of MPPE1ProteinHetionet hetionet:regulates:7150-65258Inferred only
MPPE1 requires the cofactor Mn(2+)CompoundUniProt Q53F39Inferred only

Reactions

1 reaction

[protein]-C-terminal carboxyl phosphoethanolamide-GPI(deacylinositol-H8)+water[protein]-C-terminal carboxyl phosphoethanolamide-GPI(deacylinositol-H7)+phosphoethanolamine+hydron
Catalysed by MPPE1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:83747CC BY 4.0Reference data

Other names

2 names

Resolves to: MPPE1

Also called: PGAP5Post-GPI attachment to proteins factor 5

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