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Proteins/UNIPROT:P51511

MMP15

Protein·UNIPROT:P51511

Open in the graph

Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A..

Function from UniProtKB (P51511), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

Alagille syndrome has a germline basis in MMP15DiseaseGenCC HGNC:7161|MONDO:0007318Inferred only

Statements

15 statements

15 statements · 4 reference databases · Subject: MMP15 · Sources: Hetionet, Reactome, UniProt, WikiPathways

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RTN4 covaries with MMP15ProteinHetionet hetionet:covaries:4324-57142Inferred only
COL1A2 interacts with MMP15ProteinHetionet hetionet:interacts:1278-4324Inferred only
LRP1 interacts with MMP15ProteinHetionet hetionet:interacts:4035-4324Inferred only
MMP15 interacts with PROCProteinHetionet hetionet:interacts:4324-5624Inferred only
MMP15 interacts with TIMP2ProteinHetionet hetionet:interacts:4324-7077Inferred only
MMP15 interacts with UBCProteinHetionet hetionet:interacts:4324-7316Inferred only
MMP15 participates in Activation of Matrix MetalloproteinasesPathwayReactome R-HSA-1592389Inferred only
MMP15 participates in Chronic hyperglycemia impairment of neuron functionPathwayWikiPathways WP5283Inferred only
MMP15 participates in Collagen degradationPathwayReactome R-HSA-1442490Inferred only
MMP15 participates in Degradation of the extracellular matrixPathwayReactome R-HSA-1474228Inferred only
MMP15 participates in Epithelial to mesenchymal transition in colorectal cancerPathwayWikiPathways WP4239Inferred only
MMP15 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only

Show the remaining 3

MMP15 participates in Matrix metalloproteinasesPathwayWikiPathways WP129Inferred only
MMP15 requires the cofactor Ca(2+)CompoundUniProt P51511Inferred only
MMP15 requires the cofactor Zn(2+)CompoundUniProt P51511Inferred only

Other names

8 names

Resolves to: MMP15

Also called: Membrane-type matrix metalloproteinase 2Membrane-type-2 matrix metalloproteinaseMMP-15MT-MMP 2MT2-MMPMT2MMPMTMMP2SMCP-2

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