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Proteins/UNIPROT:Q9UHC7
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription..
Function from UniProtKB (Q9UHC7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
21 statements
21 statements · 2 reference databases · Subject: MKRN1 · Sources: Hetionet, Reactome
1 reaction
3 names
Resolves to: MKRN1
Reaction pageLeft to rightBalance undeterminableEC 2.3.2.23, 2.3.2.27, 6.2.1.45cytosol
Human-GEM MAR09491CC BY 4.0Reference data