Proteins/UNIPROT:O94851

MICAL2

ProteinUNIPROT:O94851

Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA..

Function from UniProtKB (O94851), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

14 statements

14 statements · 4 reference databases · Subject: MICAL2 · Sources: gene ontology, Hetionet, UniProt, WikiPathways

Order

UBC interacts with MICAL2ProteinHetionet hetionet:interacts:7316-9645Inferred only
MICAL2 participates in VEGFA VEGFR2 signalingPathwayWikiPathways WP3888Inferred only
MICAL2 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology O94851|GO:0045944Inferred only
AHR increases the expression of MICAL2ProteinHetionet hetionet:regulates:196-9645Inferred only
CSNK1E increases the expression of MICAL2ProteinHetionet hetionet:regulates:1454-9645Inferred only
DDR1 increases the expression of MICAL2ProteinHetionet hetionet:regulates:780-9645Inferred only
PABPC1 increases the expression of MICAL2ProteinHetionet hetionet:regulates:26986-9645Inferred only
PNRC1 decreases the expression of MICAL2ProteinHetionet hetionet:regulates:10957-9645Inferred only
RPS27A increases the expression of MICAL2ProteinHetionet hetionet:regulates:6233-9645Inferred only
RPS6 increases the expression of MICAL2ProteinHetionet hetionet:regulates:6194-9645Inferred only
SOD1 increases the expression of MICAL2ProteinHetionet hetionet:regulates:6647-9645Inferred only
TCIRG1 increases the expression of MICAL2ProteinHetionet hetionet:regulates:10312-9645Inferred only

Show the remaining 2

UBB increases the expression of MICAL2ProteinHetionet hetionet:regulates:7314-9645Inferred only
MICAL2 requires the cofactor FAD(3-)CompoundUniProt O94851Inferred only

Reactions

1 reaction

L-methionyl-[F-actin]+NADPH(4-)+dioxygen+hydronL-methionyl-(R)-S-oxide-[F-actin]+NADP(3-)+water
Catalysed by MICAL2 or MICAL3 or MICAL1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:51308CC BY 4.0Reference data

Other names

8 names

Resolves to: MICAL2

Also called: KIAA0750MICAL C-terminal-like proteinMICAL-2Mical-cLMICAL2PV1MICAL2PV2MICALCLMolecule interacting with CasL protein 2

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