Proteins/UNIPROT:O00470

MEIS1

ProteinUNIPROT:O00470

Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias..

Function from UniProtKB (O00470), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

38 statements

38 statements · 4 reference databases · Subject: MEIS1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

CREB1 interacts with MEIS1ProteinHetionet hetionet:interacts:1385-4211Inferred only
EMX2 interacts with MEIS1ProteinHetionet hetionet:interacts:2018-4211Inferred only
ETS1 interacts with MEIS1ProteinHetionet hetionet:interacts:2113-4211Inferred only
HOXA10 interacts with MEIS1ProteinHetionet hetionet:interacts:3206-4211Inferred only
HOXA11 interacts with MEIS1ProteinHetionet hetionet:interacts:3207-4211Inferred only
HOXA13 interacts with MEIS1ProteinHetionet hetionet:interacts:3209-4211Inferred only
HOXA2 interacts with MEIS1ProteinHetionet hetionet:interacts:3199-4211Inferred only
HOXA5 interacts with MEIS1ProteinHetionet hetionet:interacts:3202-4211Inferred only
HOXA7 interacts with MEIS1ProteinHetionet hetionet:interacts:3204-4211Inferred only
HOXA9 interacts with MEIS1ProteinHetionet hetionet:interacts:3205-4211Inferred only
HOXB1 interacts with MEIS1ProteinHetionet hetionet:interacts:3211-4211Inferred only
MEIS1 interacts with HOXB13ProteinHetionet hetionet:interacts:10481-4211Inferred only

Show the remaining 26

HOXB4 interacts with MEIS1ProteinHetionet hetionet:interacts:3214-4211Inferred only
HOXB8 interacts with MEIS1ProteinHetionet hetionet:interacts:3218-4211Inferred only
HOXC11 interacts with MEIS1ProteinHetionet hetionet:interacts:3227-4211Inferred only
HOXC13 interacts with MEIS1ProteinHetionet hetionet:interacts:3229-4211Inferred only
HOXD11 interacts with MEIS1ProteinHetionet hetionet:interacts:3237-4211Inferred only
HOXD12 interacts with MEIS1ProteinHetionet hetionet:interacts:3238-4211Inferred only
HOXD13 interacts with MEIS1ProteinHetionet hetionet:interacts:3239-4211Inferred only
HOXD4 interacts with MEIS1ProteinHetionet hetionet:interacts:3233-4211Inferred only
HOXD9 interacts with MEIS1ProteinHetionet hetionet:interacts:3235-4211Inferred only
LYL1 interacts with MEIS1ProteinHetionet hetionet:interacts:4066-4211Inferred only
MEIS1 interacts with PBX1ProteinHetionet hetionet:interacts:4211-5087Inferred only
MEIS1 interacts with PBX3ProteinHetionet hetionet:interacts:4211-5090Inferred only
TLX1 interacts with MEIS1ProteinHetionet hetionet:interacts:3195-4211Inferred only
TLX2 interacts with MEIS1ProteinHetionet hetionet:interacts:3196-4211Inferred only
MEIS1 interacts with TLX3ProteinHetionet hetionet:interacts:30012-4211Inferred only
MEIS1 interacts with TRMT10BProteinHetionet hetionet:interacts:158234-4211Inferred only
MEIS1 participates in Activation of anterior HOX genes in hindbrain development during early embryogenesisPathwayReactome R-HSA-5617472Inferred only
MEIS1 participates in Activation of HOX genes during differentiationPathwayReactome R-HSA-5619507Inferred only
MEIS1 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
MEIS1 participates in Mesodermal commitment pathwayPathwayWikiPathways WP2857Inferred only
MEIS1 participates in NephrogenesisPathwayWikiPathways WP5052Inferred only
MEIS1 regulates negative regulation of myeloid cell differentiationBiological processgene ontology O00470|GO:0045638Inferred only
MEIS1 regulates positive regulation of cell population proliferationBiological processgene ontology O00470|GO:0008284Inferred only
MEIS1 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology O00470|GO:0045944Inferred only
CDC25A increases the expression of MEIS1ProteinHetionet hetionet:regulates:993-4211Inferred only
FZD5 increases the expression of MEIS1ProteinHetionet hetionet:regulates:7855-4211Inferred only

Other names

1 name

Resolves to: MEIS1

Also called: Homeobox protein Meis1

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