Proteins/UNIPROT:P35453

HOXD13

ProteinUNIPROT:P35453

Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity)..

Function from UniProtKB (P35453), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

6 rows

brachydactyly type D has a germline basis in HOXD13DiseaseGenCC HGNC:5136|MONDO:0007222Inferred only
brachydactyly type E has a germline basis in HOXD13DiseaseGenCC HGNC:5136|MONDO:0019677Inferred only
brachydactyly type E1 has a germline basis in HOXD13DiseaseGenCC HGNC:5136|MONDO:0007223Inferred only
brachydactyly-syndactyly syndrome has a germline basis in HOXD13DiseaseGenCC HGNC:5136|MONDO:0012544Inferred only
syndactyly type 5 has a germline basis in HOXD13DiseaseGenCC HGNC:5136|MONDO:0008516Inferred only
synpolydactyly type 1 has a germline basis in HOXD13DiseaseGenCC HGNC:5136|MONDO:0008513Inferred only

Statements

16 statements

16 statements · 2 reference databases · Subject: HOXD13 · Sources: gene ontology, Hetionet

Order

HOXD13 covaries with ABTB3ProteinHetionet hetionet:covaries:121551-3239Inferred only
HOXD13 covaries with AQP5ProteinHetionet hetionet:covaries:3239-362Inferred only
HOXD13 covaries with NEURL1ProteinHetionet hetionet:covaries:3239-9148Inferred only
HOXD13 covaries with TLX1ProteinHetionet hetionet:covaries:3195-3239Inferred only
CREB1 interacts with HOXD13ProteinHetionet hetionet:interacts:1385-3239Inferred only
CREBBP interacts with HOXD13ProteinHetionet hetionet:interacts:1387-3239Inferred only
HOXD13 interacts with HAND2ProteinHetionet hetionet:interacts:3239-9464Inferred only
HOXD13 interacts with LYL1ProteinHetionet hetionet:interacts:3239-4066Inferred only
HOXD13 interacts with MEIS1ProteinHetionet hetionet:interacts:3239-4211Inferred only
HOXD13 interacts with SMAD1ProteinHetionet hetionet:interacts:3239-4086Inferred only
HOXD13 interacts with SMAD2ProteinHetionet hetionet:interacts:3239-4087Inferred only
HOXD13 interacts with SMAD5ProteinHetionet hetionet:interacts:3239-4090Inferred only

Show the remaining 4

HOXD13 interacts with UBCProteinHetionet hetionet:interacts:3239-7316Inferred only
HOXD13 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology P35453|GO:0045944Inferred only
HOXD13 regulates regulation of DNA-templated transcriptionBiological processgene ontology P35453|GO:0006355Inferred only
HOXD13 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology P35453|GO:0006357Inferred only

Other names

3 names

Resolves to: HOXD13

Also called: Homeobox protein Hox-4IHomeobox protein Hox-D13HOX4I

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