uveal melanoma
Findings
No curated finding names uveal melanoma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A melanoma derived from melanocytes of the uveal tract. It is the most common primary intraocular tumor in the United States and Western Europe. Similar to melanoma of the skin, it is rare in Africa and Asia. Diagnostic procedures include ophthalmoscopic exam, fluorescein angiography and ultrasound. Treatment includes: surgical excision of the eye, iridocyclectomy and tumor resection. Recent treatments also include radiotherapy or photo coagulation. Classification of uveal melanomas recognizes four cell types within these tumors: epithelioid, intermediate, mixed cell, and spindle cell types. The spindle cell type uveal melanomas are further sub-classified as spindle cell type A and spindle cell type B.
Definition from the Mondo Disease Ontology (MONDO:0006486), read 2026-09-29. CC BY 4.0.
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- MBD4HGNC:6919
- Moderate · ClinGen · Autosomal dominant · 2026
Where it sits
- A kind of
Other names
7 names
Resolves to: uveal melanoma
- Also called
- intraocular melanomamelanoma (disease) of uveamelanoma of the uveamelanoma of uveamelanoma, uveal, malignantuvea melanomauvea melanoma (disease)