Proteins/UNIPROT:Q9P2E8

MARCHF4

ProteinUNIPROT:Q9P2E8

E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates..

Function from UniProtKB (Q9P2E8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

9 statements

9 statements · 1 reference database · Subject: MARCHF4 · Sources: Hetionet

Order

CYSRT1 covaries with MARCHF4ProteinHetionet hetionet:covaries:375791-57574Inferred only
MARCHF4 covaries with HAGHLProteinHetionet hetionet:covaries:57574-84264Inferred only
MARCHF4 covaries with HNRNPRProteinHetionet hetionet:covaries:10236-57574Inferred only
MARCHF4 covaries with NHLRC4ProteinHetionet hetionet:covaries:283948-57574Inferred only
OPN1LW covaries with MARCHF4ProteinHetionet hetionet:covaries:57574-5956Inferred only
MARCHF4 covaries with USP12ProteinHetionet hetionet:covaries:219333-57574Inferred only
WNT7B covaries with MARCHF4ProteinHetionet hetionet:covaries:57574-7477Inferred only
ZIC1 covaries with MARCHF4ProteinHetionet hetionet:covaries:57574-7545Inferred only
CD4 interacts with MARCHF4ProteinHetionet hetionet:interacts:57574-920Inferred only

Reactions

1 reaction

MAM00204c+ATP+MAM03105cMAM00214c+AMP+diphosphate(3-)
Catalysed by RNF40 & RNF20 or SAE1 & UBA2 or RING1 & RNF2 or HECW1 or MYCBP2 or MYLIP or UBE3C or RNF216 or UBR7 or RNF14 or UBR2

Other names

8 names

Resolves to: MARCHF4

Also called: KIAA1399MARCH-IVMARCH4Membrane-associated RING finger protein 4Membrane-associated RING-CH protein IVRING finger protein 174RING-type E3 ubiquitin transferase MARCHF4RNF174

← Every protein Find it in the graph →