Proteins/UNIPROT:Q18PE1

DOK7

ProteinUNIPROT:Q18PE1

Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK..

Function from UniProtKB (Q18PE1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

congenital myasthenic syndrome 10 has a germline basis in DOK7DiseaseGenCC HGNC:26594|MONDO:0009690Inferred only
fetal akinesia deformation sequence 1 has a germline basis in DOK7DiseaseGenCC HGNC:26594|MONDO:0100101Inferred only
fetal akinesia deformation sequence 3 has a germline basis in DOK7DiseaseGenCC HGNC:26594|MONDO:0100103Inferred only

Statements

8 statements

8 statements · 2 reference databases · Subject: DOK7 · Sources: gene ontology, Hetionet

Order

DOK7 covaries with C16orf90ProteinHetionet hetionet:covaries:285489-646174Inferred only
GRIP2 covaries with DOK7ProteinHetionet hetionet:covaries:285489-80852Inferred only
HTRA3 covaries with DOK7ProteinHetionet hetionet:covaries:285489-94031Inferred only
SH3TC1 covaries with DOK7ProteinHetionet hetionet:covaries:285489-54436Inferred only
DOK7 covaries with ZBTB8OSProteinHetionet hetionet:covaries:285489-339487Inferred only
MUSK interacts with DOK7ProteinHetionet hetionet:interacts:285489-4593Inferred only
DOK7 regulates positive regulation of protein tyrosine kinase activityBiological processgene ontology Q18PE1|GO:0061098Inferred only
DOK7 regulates positive regulation of Rac protein signal transductionBiological processgene ontology Q18PE1|GO:0035022Inferred only

Other names

4 names

Resolves to: DOK7

Also called: C4orf25Dok-7Downstream of tyrosine kinase 7Protein Dok-7

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