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Proteins/UNIPROT:P54198

HIRA

Protein·UNIPROT:P54198

Open in the graph

Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit..

Function from UniProtKB (P54198), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

neurodevelopmental disorder has a germline basis in HIRADiseaseGenCC HGNC:4916|MONDO:0700092Inferred only

Statements

30 statements

30 statements · 4 reference databases · Subject: HIRA · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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PI4KA covaries with HIRAProteinHetionet hetionet:covaries:5297-7290Inferred only
HIRA covaries with SVIPProteinHetionet hetionet:covaries:258010-7290Inferred only
HIRA interacts with ASF1AProteinHetionet hetionet:interacts:25842-7290Inferred only
HIRA interacts with ASF1BProteinHetionet hetionet:interacts:55723-7290Inferred only
CCNA2 interacts with HIRAProteinHetionet hetionet:interacts:7290-890Inferred only
CDK2 interacts with HIRAProteinHetionet hetionet:interacts:1017-7290Inferred only
HIRA interacts with DNAJA2ProteinHetionet hetionet:interacts:10294-7290Inferred only
HIRA interacts with H2BC12ProteinHetionet hetionet:interacts:7290-85236Inferred only
HIRA interacts with H2BC21ProteinHetionet hetionet:interacts:7290-8349Inferred only
H2BC4; H2BC6; H2BC7; H2BC8; H2BC10 interacts with HIRAProteinHetionet hetionet:interacts:3017-7290Inferred only
HIRA interacts with HIRIP3ProteinHetionet hetionet:interacts:7290-8479Inferred only
HIRA interacts with NFU1ProteinHetionet hetionet:interacts:27247-7290Inferred only

Show the remaining 18

PAX7 interacts with HIRAProteinHetionet hetionet:interacts:5081-7290Inferred only
HIRA interacts with SUMO1ProteinHetionet hetionet:interacts:7290-7341Inferred only
HIRA interacts with UBCProteinHetionet hetionet:interacts:7290-7316Inferred only
HIRA interacts with UBN1ProteinHetionet hetionet:interacts:29855-7290Inferred only
UPF1 interacts with HIRAProteinHetionet hetionet:interacts:5976-7290Inferred only
HIRA participates in 16p11 2 proximal deletion syndromePathwayWikiPathways WP4949Inferred only
HIRA participates in 22q11 2 copy number variation syndromePathwayWikiPathways WP4657Inferred only
HIRA participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
HIRA participates in Cellular responses to stressPathwayReactome R-HSA-2262752Inferred only
HIRA participates in Cellular SenescencePathwayReactome R-HSA-2559583Inferred only
HIRA participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
HIRA participates in DNA Damage/Telomere Stress Induced SenescencePathwayReactome R-HSA-2559586Inferred only
HIRA participates in Formation of Senescence-Associated Heterochromatin Foci (SAHF)PathwayReactome R-HSA-2559584Inferred only
HIRA participates in Maternal to zygotic transition (MZT)PathwayReactome R-HSA-9816359Inferred only
HIRA participates in Replacement of protamines by nucleosomes in the male pronucleusPathwayReactome R-HSA-9821993Inferred only
HIRA participates in Tessadori Bicknell van Haaften syndrome variants nucleosome assemblyPathwayWikiPathways WP5573Inferred only
HIRA regulates regulation of chromatin organizationBiological processgene ontology P54198|GO:1902275Inferred only
HIRA regulates regulation of transcription by RNA polymerase IIBiological processgene ontology P54198|GO:0006357Inferred only

Other names

5 names

Resolves to: HIRA

Also called: DGCR1HIRProtein HIRATUP1-like enhancer of split protein 1TUPLE1

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