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Proteins/UNIPROT:Q5T8I9
Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis..
Function from UniProtKB (Q5T8I9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
10 statements
10 statements · 4 reference databases · Subject: HENMT1 · Sources: Bgee, Hetionet, Reactome, UniProt
1 reaction
CHEBI:74896+S-adenosyl-L-methionineCHEBI:74898+S-adenosyl-L-homocysteine+hydron
Catalysed by HENMT1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:37887CC BY 4.0Reference data
2 names
Resolves to: HENMT1