Proteins/UNIPROT:Q8N442

GUF1

ProteinUNIPROT:Q8N442

Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner..

Function from UniProtKB (Q8N442), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

10 statements

10 statements · 2 reference databases · Subject: GUF1 · Sources: gene ontology, Hetionet

Order

OR4K14 covaries with GUF1ProteinHetionet hetionet:covaries:122740-60558Inferred only
GUF1 covaries with SF3A2ProteinHetionet hetionet:covaries:60558-8175Inferred only
UBD interacts with GUF1ProteinHetionet hetionet:interacts:10537-60558Inferred only
GUF1 regulates positive regulation of translationBiological processgene ontology Q8N442|GO:0045727Inferred only
DHX29 increases the expression of GUF1ProteinHetionet hetionet:regulates:54505-60558Inferred only
HOXA5 increases the expression of GUF1ProteinHetionet hetionet:regulates:3202-60558Inferred only
NOTCH1 increases the expression of GUF1ProteinHetionet hetionet:regulates:4851-60558Inferred only
NQO1 increases the expression of GUF1ProteinHetionet hetionet:regulates:1728-60558Inferred only
RPS13 increases the expression of GUF1ProteinHetionet hetionet:regulates:6207-60558Inferred only
TFEB increases the expression of GUF1ProteinHetionet hetionet:regulates:7942-60558Inferred only

Reactions

1 reaction

GTP+waterGDP+hydrogenphosphate+hydron
Catalysed by IRGM or RAB19 or TUBAL3 or GTPBP1 or RAB27B or RHOD or DNM1L or MRAS or RAB29 or OPA1 or EIF5B or ENTPD3 and 183 more alternatives
Reaction page

Other names

4 names

Resolves to: GUF1

Also called: EF-4Elongation factor 4 homologGTPase GUF1Ribosomal back-translocase

← Every protein Find it in the graph →