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Proteins/UNIPROT:P30968

GNRHR

Protein·UNIPROT:P30968

Open in the graph

Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.

Function from UniProtKB (P30968), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

hypogonadotropic hypogonadism has a germline basis in GNRHRDiseaseGenCC HGNC:4421|MONDO:0018555Inferred only
hypogonadotropic hypogonadism 7 with or without anosmia has a germline basis in GNRHRDiseaseGenCC HGNC:4421|MONDO:0007794Inferred only

Statements

11 statements

11 statements · 3 reference databases · Subject: GNRHR · Sources: Hetionet, Reactome, WikiPathways

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GNRH1 interacts with GNRHRProteinHetionet hetionet:interacts:2796-2798Inferred only
GNRHR interacts with RGS10ProteinHetionet hetionet:interacts:2798-6001Inferred only
GNRHR participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
GNRHR participates in G alpha (q) signalling eventsPathwayReactome R-HSA-416476Inferred only
GNRHR participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
GNRHR participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
GNRHR participates in GPCRs otherPathwayWikiPathways WP117Inferred only
GNRHR participates in Hormone ligand-binding receptorsPathwayReactome R-HSA-375281Inferred only
GNRHR participates in Peptide GPCRsPathwayWikiPathways WP24Inferred only
GNRHR participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
GNRHR participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only

Other names

3 names

Resolves to: GNRHR

Also called: GnRH receptorGnRH-RGRHR

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