Proteins/UNIPROT:O43665

RGS10

ProteinUNIPROT:O43665

Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G protein..

Function from UniProtKB (O43665), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

23 statements

23 statements · 4 reference databases · Subject: RGS10 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

CD33 covaries with RGS10ProteinHetionet hetionet:covaries:6001-945Inferred only
APP interacts with RGS10ProteinHetionet hetionet:interacts:351-6001Inferred only
CALM1 interacts with RGS10ProteinHetionet hetionet:interacts:6001-801Inferred only
CALM1 interacts with RGS10ProteinHetionet hetionet:interacts:6001-808Inferred only
CALM1 interacts with RGS10ProteinHetionet hetionet:interacts:6001-805Inferred only
GNAI1 interacts with RGS10ProteinHetionet hetionet:interacts:2770-6001Inferred only
GNAI3 interacts with RGS10ProteinHetionet hetionet:interacts:2773-6001Inferred only
GNAO1 interacts with RGS10ProteinHetionet hetionet:interacts:2775-6001Inferred only
GNAZ interacts with RGS10ProteinHetionet hetionet:interacts:2781-6001Inferred only
GNRHR interacts with RGS10ProteinHetionet hetionet:interacts:2798-6001Inferred only
PRKACA interacts with RGS10ProteinHetionet hetionet:interacts:5566-6001Inferred only
RGS10 interacts with SAP18ProteinHetionet hetionet:interacts:10284-6001Inferred only

Show the remaining 11

RGS10 interacts with UBCProteinHetionet hetionet:interacts:6001-7316Inferred only
RGS10 participates in Calcium regulation in cardiac cellsPathwayWikiPathways WP536Inferred only
RGS10 participates in Endoderm differentiationPathwayWikiPathways WP2853Inferred only
RGS10 participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only
RGS10 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
RGS10 participates in Mesodermal commitment pathwayPathwayWikiPathways WP2857Inferred only
RGS10 participates in Myometrial relaxation and contraction pathwaysPathwayWikiPathways WP289Inferred only
RGS10 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
RGS10 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
RGS10 regulates positive regulation of GTPase activityBiological processgene ontology O43665|GO:0043547Inferred only
RGS10 regulates regulation of G protein-coupled receptor signaling pathwayBiological processgene ontology O43665|GO:0008277Inferred only

Other names

1 name

Resolves to: RGS10

Also called: Regulator of G protein signaling 10

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