Proteins/UNIPROT:O00451

GFRA2

ProteinUNIPROT:O00451

Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons. NRTN-binding leads to autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor..

[Isoform 2]: Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3..

Function from UniProtKB (O00451), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

13 statements

13 statements · 2 reference databases · Subject: GFRA2 · Sources: Hetionet, Reactome

Order

SIGMAR1 covaries with GFRA2ProteinHetionet hetionet:covaries:10280-2675Inferred only
GDNF interacts with GFRA2ProteinHetionet hetionet:interacts:2668-2675Inferred only
GFRA2 interacts with NRTNProteinHetionet hetionet:interacts:2675-4902Inferred only
GFRA2 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
GFRA2 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
GFRA2 participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
GFRA2 participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
GFRA2 participates in NCAM signaling for neurite out-growthPathwayReactome R-HSA-375165Inferred only
GFRA2 participates in NCAM1 interactionsPathwayReactome R-HSA-419037Inferred only
GFRA2 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
GFRA2 participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
GFRA2 participates in RET signalingPathwayReactome R-HSA-8853659Inferred only

Show the remaining 1

GFRA2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only

Other names

13 names

Resolves to: GFRA2

Also called: GDNF receptor alpha-2GDNF receptor betaGDNFR-alpha-2GDNFR-betaGDNFRBGFR-alpha-2Neurturin receptor alphaNRTNR-alphaNTNR-alphaRET ligand 2RETL2TGF-beta-related neurotrophic factor receptor 2TRNR2

← Every protein Find it in the graph →