Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P39905

GDNF

Protein·UNIPROT:P39905

Open in the graph

Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Acts by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor. Involved in the development of the neural crest..

Function from UniProtKB (P39905), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

37 statements

37 statements · 4 reference databases · Subject: GDNF · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Search this listOrder

GDNF covaries with PABPC1L2A; PABPC1L2BProteinHetionet hetionet:covaries:2668-340529Inferred only
GDNF interacts with COPS5ProteinHetionet hetionet:interacts:10987-2668Inferred only
GDNF interacts with GFRA1ProteinHetionet hetionet:interacts:2668-2674Inferred only
GDNF interacts with GFRA2ProteinHetionet hetionet:interacts:2668-2675Inferred only
GDNF participates in Allograft rejectionPathwayWikiPathways WP2328Inferred only
GDNF participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
GDNF participates in Development of ureteric derived collecting systemPathwayWikiPathways WP5053Inferred only
GDNF participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
GDNF participates in Formation of the ureteric budPathwayReactome R-HSA-9830674Inferred only
GDNF participates in GDNF RET signaling axisPathwayWikiPathways WP4830Inferred only
GDNF participates in Genes controlling nephrogenesisPathwayWikiPathways WP4823Inferred only
GDNF participates in Kidney developmentPathwayReactome R-HSA-9830369Inferred only

Show the remaining 25

GDNF participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
GDNF participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
GDNF participates in Markers of kidney cell lineagePathwayWikiPathways WP5236Inferred only
GDNF participates in NCAM signaling for neurite out-growthPathwayReactome R-HSA-375165Inferred only
GDNF participates in NCAM1 interactionsPathwayReactome R-HSA-419037Inferred only
GDNF participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
GDNF participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
GDNF participates in RET signalingPathwayReactome R-HSA-8853659Inferred only
GDNF participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
GDNF participates in Spinal cord injuryPathwayWikiPathways WP2431Inferred only
GDNF regulates negative regulation of apoptotic processBiological processgene ontology P39905|GO:0043066Inferred only
GDNF regulates negative regulation of extrinsic apoptotic signaling pathway in absence of ligandBiological processgene ontology P39905|GO:2001240Inferred only
GDNF regulates negative regulation of neuron apoptotic processBiological processgene ontology P39905|GO:0043524Inferred only
GDNF regulates positive regulation of branching involved in ureteric bud morphogenesisBiological processgene ontology P39905|GO:0090190Inferred only
GDNF regulates positive regulation of cell differentiationBiological processgene ontology P39905|GO:0045597Inferred only
GDNF regulates positive regulation of cell population proliferationBiological processgene ontology P39905|GO:0008284Inferred only
GDNF regulates positive regulation of dopamine secretionBiological processgene ontology P39905|GO:0033603Inferred only
GDNF regulates positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisBiological processgene ontology P39905|GO:0072108Inferred only
GDNF regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology P39905|GO:0045944Inferred only
GDNF regulates positive regulation of ureteric bud formationBiological processgene ontology P39905|GO:0072107Inferred only
GDNF regulates regulation of dopamine uptake involved in synaptic transmissionBiological processgene ontology P39905|GO:0051584Inferred only
GDNF regulates regulation of gene expressionBiological processgene ontology P39905|GO:0010468Inferred only
GDNF regulates regulation of morphogenesis of a branching structureBiological processgene ontology P39905|GO:0060688Inferred only
GDNF regulates regulation of semaphorin-plexin signaling pathwayBiological processgene ontology P39905|GO:2001260Inferred only
GDNF regulates regulation of stem cell differentiationBiological processgene ontology P39905|GO:2000736Inferred only

Other names

3 names

Resolves to: GDNF

Also called: Astrocyte-derived trophic factorATFhGDNF

← Every protein Find it in the graph →