Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P01225

FSHB

Protein·UNIPROT:P01225

Open in the graph

Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs..

Function from UniProtKB (P01225), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

hypogonadotropic hypogonadism 24 without anosmia has a germline basis in FSHBDiseaseGenCC HGNC:3964|MONDO:0009239Inferred only

Statements

23 statements

23 statements · 4 reference databases · Subject: FSHB · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Search this listOrder

CGA interacts with FSHBProteinHetionet hetionet:interacts:1081-2488Inferred only
FSHB interacts with CGB3; CGB5; CGB8ProteinHetionet hetionet:interacts:2488-93659Inferred only
FSHB interacts with CGB3; CGB5; CGB8ProteinHetionet hetionet:interacts:2488-94115Inferred only
CGB3; CGB5; CGB8 interacts with FSHBProteinHetionet hetionet:interacts:1082-2488Inferred only
FSHB interacts with FSHRProteinHetionet hetionet:interacts:2488-2492Inferred only
FSHB participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
FSHB participates in Follicle stimulating hormone FSH signalingPathwayWikiPathways WP2035Inferred only
FSHB participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
FSHB participates in Glycoprotein hormonesPathwayReactome R-HSA-209822Inferred only
FSHB participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
FSHB participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
FSHB participates in Hormone ligand-binding receptorsPathwayReactome R-HSA-375281Inferred only

Show the remaining 11

FSHB participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
FSHB participates in Orexin receptor pathwayPathwayWikiPathways WP5094Inferred only
FSHB participates in Peptide hormone biosynthesisPathwayReactome R-HSA-209952Inferred only
FSHB participates in Peptide hormone metabolismPathwayReactome R-HSA-2980736Inferred only
FSHB participates in Prader Willi and Angelman syndromePathwayWikiPathways WP3998Inferred only
FSHB participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
FSHB participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
FSHB regulates positive regulation of cell migrationBiological processgene ontology P01225|GO:0030335Inferred only
FSHB regulates positive regulation of cell population proliferationBiological processgene ontology P01225|GO:0008284Inferred only
FSHB regulates positive regulation of steroid biosynthetic processBiological processgene ontology P01225|GO:0010893Inferred only
FSHB regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology P01225|GO:0045944Inferred only

Other names

4 names

Resolves to: FSHB

Also called: Follicle-stimulating hormone beta subunitFollitropin beta chainFSH-BFSH-beta

← Every protein Find it in the graph →