Proteins/UNIPROT:A1A519

FAM170A

ProteinUNIPROT:A1A519

Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE). Necessary for normal sperm head morphology, efficient spermiation, and sperm progressive motility (By similarity). Plays a crucial role in sperm chromatin remodeling by promoting the nuclear translocation and deubiquitinating activity of USP7 on histone H2A and H2B variants (By similarity). This ensures the timely removal of core histones, proper expression and degradation of transition proteins, and efficient incorporation of protamines during spermiogenesis (By similarity)..

Function from UniProtKB (A1A519), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

6 statements

6 statements · 2 reference databases · Subject: FAM170A · Sources: gene ontology, Hetionet

Order

FAM170A covaries with C1orf94ProteinHetionet hetionet:covaries:340069-84970Inferred only
FAM170A covaries with FREY1ProteinHetionet hetionet:covaries:143678-340069Inferred only
RP9 covaries with FAM170AProteinHetionet hetionet:covaries:340069-6100Inferred only
FAM170A regulates positive regulation of DNA-templated transcriptionBiological processgene ontology A1A519|GO:0045893Inferred only
FAM170A regulates positive regulation of protein deubiquitinationBiological processgene ontology A1A519|GO:1903003Inferred only
FAM170A regulates positive regulation of protein import into nucleusBiological processgene ontology A1A519|GO:0042307Inferred only

Other names

3 names

Resolves to: FAM170A

Also called: Zinc finger domain-containing proteinZinc finger protein ZNFDZNFD

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