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Proteins/UNIPROT:O75593

FOXH1

Protein·UNIPROT:O75593

Open in the graph

Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element)..

Function from UniProtKB (O75593), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

congenital heart disease has a germline basis in FOXH1DiseaseGenCC HGNC:3814|MONDO:0005453Inferred only

Statements

28 statements

28 statements · 4 reference databases · Subject: FOXH1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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FOXH1 covaries with SAMD10ProteinHetionet hetionet:covaries:140700-8928Inferred only
FOXH1 interacts with DRAP1ProteinHetionet hetionet:interacts:10589-8928Inferred only
FOXH1 interacts with ELAC2ProteinHetionet hetionet:interacts:60528-8928Inferred only
FOXG1 interacts with FOXH1ProteinHetionet hetionet:interacts:2290-8928Inferred only
GRB2 interacts with FOXH1ProteinHetionet hetionet:interacts:2885-8928Inferred only
NCK1 interacts with FOXH1ProteinHetionet hetionet:interacts:4690-8928Inferred only
NKX2-5 interacts with FOXH1ProteinHetionet hetionet:interacts:1482-8928Inferred only
PIK3R1 interacts with FOXH1ProteinHetionet hetionet:interacts:5295-8928Inferred only
SMAD2 interacts with FOXH1ProteinHetionet hetionet:interacts:4087-8928Inferred only
SMAD3 interacts with FOXH1ProteinHetionet hetionet:interacts:4088-8928Inferred only
SMAD4 interacts with FOXH1ProteinHetionet hetionet:interacts:4089-8928Inferred only
FOXH1 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only

Show the remaining 16

FOXH1 participates in Endoderm differentiationPathwayWikiPathways WP2853Inferred only
FOXH1 participates in Formation of axial mesodermPathwayReactome R-HSA-9796292Inferred only
FOXH1 participates in GastrulationPathwayReactome R-HSA-9758941Inferred only
FOXH1 participates in Germ layer formation at gastrulationPathwayReactome R-HSA-9754189Inferred only
FOXH1 participates in Heart developmentPathwayWikiPathways WP1591Inferred only
FOXH1 participates in Mesodermal commitment pathwayPathwayWikiPathways WP2857Inferred only
FOXH1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
FOXH1 participates in Signaling by ActivinPathwayReactome R-HSA-1502540Inferred only
FOXH1 participates in Signaling by NODALPathwayReactome R-HSA-1181150Inferred only
FOXH1 participates in Signaling by TGFB family membersPathwayReactome R-HSA-9006936Inferred only
FOXH1 participates in TGF beta receptor signalingPathwayWikiPathways WP560Inferred only
FOXH1 participates in TGF beta receptor signaling in skeletal dysplasiasPathwayWikiPathways WP4816Inferred only
FOXH1 regulates negative regulation of androgen receptor signaling pathwayBiological processgene ontology O75593|GO:0060766Inferred only
FOXH1 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology O75593|GO:0000122Inferred only
FOXH1 regulates positive regulation of DNA-templated transcriptionBiological processgene ontology O75593|GO:0045893Inferred only
FOXH1 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology O75593|GO:0045944Inferred only

Other names

7 names

Resolves to: FOXH1

Also called: Fast-1Fast-2FAST1FAST2Forkhead activin signal transducer 1Forkhead activin signal transducer 2hFAST-1

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