Proteins/UNIPROT:P55075

FGF8

ProteinUNIPROT:P55075

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells..

Function from UniProtKB (P55075), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

5 rows

congenital heart disease has a germline basis in FGF8DiseaseGenCC HGNC:3686|MONDO:0005453Inferred only
femoral agenesis/hypoplasia has a germline basis in FGF8DiseaseGenCC HGNC:3686|MONDO:0016032Inferred only
hypogonadotropic hypogonadism has a germline basis in FGF8DiseaseGenCC HGNC:3686|MONDO:0018555Inferred only
hypogonadotropic hypogonadism 6 with or without anosmia has a germline basis in FGF8DiseaseGenCC HGNC:3686|MONDO:0012988Inferred only
Kallmann syndrome has a germline basis in FGF8DiseaseGenCC HGNC:3686|MONDO:0018800Inferred only

Statements

36 statements

36 statements · 4 reference databases · Subject: FGF8 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

BAALC covaries with FGF8ProteinHetionet hetionet:covaries:2253-79870Inferred only
FGF8 covaries with MEX3AProteinHetionet hetionet:covaries:2253-92312Inferred only
FGF8 covaries with WNT3AProteinHetionet hetionet:covaries:2253-89780Inferred only
ZSCAN2 covaries with FGF8ProteinHetionet hetionet:covaries:2253-54993Inferred only
FGF8 interacts with FGFR1ProteinHetionet hetionet:interacts:2253-2260Inferred only
FGF8 interacts with FGFR3ProteinHetionet hetionet:interacts:2253-2261Inferred only
FGF8 interacts with FGFR4ProteinHetionet hetionet:interacts:2253-2264Inferred only
FGF8 participates in 22q11 2 copy number variation syndromePathwayWikiPathways WP4657Inferred only
FGF8 participates in Breast cancer pathwayPathwayWikiPathways WP4262Inferred only
FGF8 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
FGF8 participates in Dopaminergic neurogenesisPathwayWikiPathways WP2855Inferred only
FGF8 participates in Embryonic stem cell pluripotency pathwaysPathwayWikiPathways WP3931Inferred only

Show the remaining 24

FGF8 participates in Focal adhesion PI3K Akt mTOR signalingPathwayWikiPathways WP3932Inferred only
FGF8 participates in Formation of the posterior neural platePathwayReactome R-HSA-9832991Inferred only
FGF8 participates in GastrulationPathwayReactome R-HSA-9758941Inferred only
FGF8 participates in Gene regulatory network modeling somitogenesis PathwayWikiPathways WP2854Inferred only
FGF8 participates in Genes controlling nephrogenesisPathwayWikiPathways WP4823Inferred only
FGF8 participates in Heart developmentPathwayWikiPathways WP1591Inferred only
FGF8 participates in Kallmann syndromePathwayWikiPathways WP5074Inferred only
FGF8 participates in MAPK signalingPathwayWikiPathways WP382Inferred only
FGF8 participates in Markers of kidney cell lineagePathwayWikiPathways WP5236Inferred only
FGF8 participates in Mesodermal commitment pathwayPathwayWikiPathways WP2857Inferred only
FGF8 participates in NephrogenesisPathwayWikiPathways WP5052Inferred only
FGF8 participates in Neural crest differentiationPathwayWikiPathways WP2064Inferred only
FGF8 participates in Osteoblast differentiation and related diseasesPathwayWikiPathways WP4787Inferred only
FGF8 participates in PI3K Akt signalingPathwayWikiPathways WP4172Inferred only
FGF8 participates in Pleural mesotheliomaPathwayWikiPathways WP5087Inferred only
FGF8 participates in Pluripotent stem cell differentiation pathwayPathwayWikiPathways WP2848Inferred only
FGF8 participates in Regulation of actin cytoskeletonPathwayWikiPathways WP51Inferred only
FGF8 participates in Tgif disruption of Shh signalingPathwayWikiPathways WP3674Inferred only
FGF8 regulates negative regulation of cardiac muscle tissue developmentBiological processgene ontology P55075|GO:0055026Inferred only
FGF8 regulates positive regulation of cell differentiationBiological processgene ontology P55075|GO:0045597Inferred only
FGF8 regulates positive regulation of cell population proliferationBiological processgene ontology P55075|GO:0008284Inferred only
FGF8 regulates positive regulation of gene expressionBiological processgene ontology P55075|GO:0010628Inferred only
FGF8 regulates positive regulation of MAPK cascadeBiological processgene ontology P55075|GO:0043410Inferred only
FGF8 regulates regulation of cell migrationBiological processgene ontology P55075|GO:0030334Inferred only

Other names

5 names

Resolves to: FGF8

Also called: AIGFAndrogen-induced growth factorFGF-8HBGF-8Heparin-binding growth factor 8

← Every protein Find it in the graph →