Proteins/UNIPROT:Q6IA86

ELP2

ProteinUNIPROT:Q6IA86

Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs..

Function from UniProtKB (Q6IA86), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

complex neurodevelopmental disorder with motor features has a germline basis in ELP2DiseaseGenCC HGNC:18248|MONDO:0100516Inferred only
intellectual disability, autosomal recessive 58 has a germline basis in ELP2DiseaseGenCC HGNC:18248|MONDO:0014996Inferred only

Statements

23 statements

23 statements · 3 reference databases · Subject: ELP2 · Sources: gene ontology, Hetionet, Reactome

Order

ADGRG4 covaries with ELP2ProteinHetionet hetionet:covaries:139378-55250Inferred only
ELP2 covaries with ARHGAP9ProteinHetionet hetionet:covaries:55250-64333Inferred only
KLLN covaries with ELP2ProteinHetionet hetionet:covaries:100144748-55250Inferred only
LUZP4 covaries with ELP2ProteinHetionet hetionet:covaries:51213-55250Inferred only
ELP2 covaries with NEMFProteinHetionet hetionet:covaries:55250-9147Inferred only
ZNF226 covaries with ELP2ProteinHetionet hetionet:covaries:55250-7769Inferred only
ZNF331 covaries with ELP2ProteinHetionet hetionet:covaries:55250-55422Inferred only
ZNF470 covaries with ELP2ProteinHetionet hetionet:covaries:388566-55250Inferred only
ZNF554 covaries with ELP2ProteinHetionet hetionet:covaries:115196-55250Inferred only
ELP1 interacts with ELP2ProteinHetionet hetionet:interacts:55250-8518Inferred only
ETS1 interacts with ELP2ProteinHetionet hetionet:interacts:2113-55250Inferred only
JAK1 interacts with ELP2ProteinHetionet hetionet:interacts:3716-55250Inferred only

Show the remaining 11

JAK2 interacts with ELP2ProteinHetionet hetionet:interacts:3717-55250Inferred only
ELP2 interacts with MMS19ProteinHetionet hetionet:interacts:55250-64210Inferred only
STAT1 interacts with ELP2ProteinHetionet hetionet:interacts:55250-6772Inferred only
STAT3 interacts with ELP2ProteinHetionet hetionet:interacts:55250-6774Inferred only
STAT5B interacts with ELP2ProteinHetionet hetionet:interacts:55250-6777Inferred only
UBC interacts with ELP2ProteinHetionet hetionet:interacts:55250-7316Inferred only
ELP2 participates in Chromatin modifying enzymesPathwayReactome R-HSA-3247509Inferred only
ELP2 participates in Chromatin organizationPathwayReactome R-HSA-4839726Inferred only
ELP2 participates in HATs acetylate histonesPathwayReactome R-HSA-3214847Inferred only
ELP2 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q6IA86|GO:0006357Inferred only
ELP2 regulates regulation of translationBiological processgene ontology Q6IA86|GO:0006417Inferred only

Other names

4 names

Resolves to: ELP2

Also called: SHINC-2STAT3-interacting protein 1STATIP1StIP1

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