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Proteins/UNIPROT:P14138

EDN3

Protein·UNIPROT:P14138

Open in the graph

Endothelins are endothelium-derived vasoconstrictor peptides.

Function from UniProtKB (P14138), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

Waardenburg syndrome type 4B has a germline basis in EDN3DiseaseGenCC HGNC:3178|MONDO:0013201Inferred only
Waardenburg-Shah syndrome has a germline basis in EDN3DiseaseGenCC HGNC:3178|MONDO:0019518Inferred only

Statements

30 statements

30 statements · 3 reference databases · Subject: EDN3 · Sources: gene ontology, Hetionet, Reactome

Search this listOrder

EDN3 covaries with CLBA1ProteinHetionet hetionet:covaries:122616-1908Inferred only
EDN3 covaries with RBP7ProteinHetionet hetionet:covaries:116362-1908Inferred only
REXO4 covaries with EDN3ProteinHetionet hetionet:covaries:1908-57109Inferred only
SNX8 covaries with EDN3ProteinHetionet hetionet:covaries:1908-29886Inferred only
CMA1 interacts with EDN3ProteinHetionet hetionet:interacts:1215-1908Inferred only
CTSE interacts with EDN3ProteinHetionet hetionet:interacts:1510-1908Inferred only
EDN3 interacts with EDNRAProteinHetionet hetionet:interacts:1908-1909Inferred only
EDN3 interacts with EDNRBProteinHetionet hetionet:interacts:1908-1910Inferred only
EDN3 interacts with KELProteinHetionet hetionet:interacts:1908-3792Inferred only
EDN3 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
EDN3 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
EDN3 participates in G alpha (q) signalling eventsPathwayReactome R-HSA-416476Inferred only

Show the remaining 18

EDN3 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
EDN3 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
EDN3 participates in MITF-M-regulated melanocyte developmentPathwayReactome R-HSA-9730414Inferred only
EDN3 participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only
EDN3 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
EDN3 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
EDN3 participates in Transcriptional and post-translational regulation of MITF-M expression and activityPathwayReactome R-HSA-9856649Inferred only
EDN3 regulates positive regulation of cell differentiationBiological processgene ontology P14138|GO:0045597Inferred only
EDN3 regulates positive regulation of cell population proliferationBiological processgene ontology P14138|GO:0008284Inferred only
EDN3 regulates positive regulation of heart rateBiological processgene ontology P14138|GO:0010460Inferred only
EDN3 regulates positive regulation of hormone secretionBiological processgene ontology P14138|GO:0046887Inferred only
EDN3 regulates positive regulation of leukocyte chemotaxisBiological processgene ontology P14138|GO:0002690Inferred only
EDN3 regulates positive regulation of MAPK cascadeBiological processgene ontology P14138|GO:0043410Inferred only
EDN3 regulates positive regulation of mitotic nuclear divisionBiological processgene ontology P14138|GO:0045840Inferred only
EDN3 regulates positive regulation of smooth muscle contractionBiological processgene ontology P14138|GO:0045987Inferred only
EDN3 regulates regulation of gene expressionBiological processgene ontology P14138|GO:0010468Inferred only
EDN3 regulates regulation of systemic arterial blood pressure by endothelinBiological processgene ontology P14138|GO:0003100Inferred only
EDN3 regulates regulation of vasoconstrictionBiological processgene ontology P14138|GO:0019229Inferred only

Other names

3 names

Resolves to: EDN3

Also called: ET-3PPET3Preproendothelin-3

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