Proteins/UNIPROT:Q9BTV6

DPH7

ProteinUNIPROT:Q9BTV6

Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta)..

Function from UniProtKB (Q9BTV6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

9 statements

9 statements · 3 reference databases · Subject: DPH7 · Sources: Hetionet, Reactome, Rhea

Order

DPH7 covaries with COBLProteinHetionet hetionet:covaries:23242-92715Inferred only
DPH7 covaries with MRAPProteinHetionet hetionet:covaries:56246-92715Inferred only
DPH7 covaries with MROH1ProteinHetionet hetionet:covaries:727957-92715Inferred only
UBC interacts with DPH7ProteinHetionet hetionet:interacts:7316-92715Inferred only
DPH7 participates in Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activationPathwayReactome R-HSA-163841Inferred only
DPH7 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
DPH7 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
DPH7 participates in Synthesis of diphthamide-EEF2PathwayReactome R-HSA-5358493Inferred only
methanol is a substrate of DPH7CompoundRhea RHEA:42656Inferred only

Reactions

1 reaction

diphthine methyl ester-[translation elongation factor 2]+waterdiphthine-[translation elongation factor 2]+methanol+hydron
Catalysed by DPH7
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:42656CC BY 4.0Reference data

Other names

4 names

Resolves to: DPH7

Also called: C9orf112Diphthamide biosynthesis protein 7WD repeat-containing protein 85WDR85

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