Proteins/UNIPROT:Q9UK85

DKKL1

ProteinUNIPROT:Q9UK85

Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility..

Function from UniProtKB (Q9UK85), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

12 statements

12 statements · 2 reference databases · Subject: DKKL1 · Sources: gene ontology, Hetionet

Order

DGKK covaries with DKKL1ProteinHetionet hetionet:covaries:139189-27120Inferred only
EIF2B4 covaries with DKKL1ProteinHetionet hetionet:covaries:27120-8890Inferred only
DKKL1 covaries with PDE4CProteinHetionet hetionet:covaries:27120-5143Inferred only
TMEM225B covaries with DKKL1ProteinHetionet hetionet:covaries:100289187-27120Inferred only
ABL1 interacts with DKKL1ProteinHetionet hetionet:interacts:25-27120Inferred only
DKKL1 interacts with C11orf71ProteinHetionet hetionet:interacts:27120-54494Inferred only
CRK interacts with DKKL1ProteinHetionet hetionet:interacts:1398-27120Inferred only
FJX1 interacts with DKKL1ProteinHetionet hetionet:interacts:24147-27120Inferred only
FYN interacts with DKKL1ProteinHetionet hetionet:interacts:2534-27120Inferred only
DKKL1 regulates negative regulation of canonical Wnt signaling pathwayBiological processgene ontology Q9UK85|GO:0090090Inferred only
DKKL1 regulates negative regulation of testosterone biosynthetic processBiological processgene ontology Q9UK85|GO:2000225Inferred only
DKKL1 regulates positive regulation of apoptotic processBiological processgene ontology Q9UK85|GO:0043065Inferred only

Other names

6 names

Resolves to: DKKL1

Also called: Cancer/testis antigen 34CT34Protein soggy-1SGY-1SGY1soggy-1

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