Proteins/UNIPROT:O14529

CUX2

ProteinUNIPROT:O14529

Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence-specific manner..

Function from UniProtKB (O14529), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

developmental and epileptic encephalopathy, 67 has a germline basis in CUX2DiseaseGenCC HGNC:19347|MONDO:0029138Inferred only
genetic developmental and epileptic encephalopathy has a germline basis in CUX2DiseaseGenCC HGNC:19347|MONDO:0100062Inferred only
Lennox-Gastaut syndrome has a germline basis in CUX2DiseaseGenCC HGNC:19347|MONDO:0016532Inferred only

Statements

18 statements

18 statements · 2 reference databases · Subject: CUX2 · Sources: gene ontology, Hetionet

Order

AGFG2 covaries with CUX2ProteinHetionet hetionet:covaries:23316-3268Inferred only
CFD covaries with CUX2ProteinHetionet hetionet:covaries:1675-23316Inferred only
DAXX covaries with CUX2ProteinHetionet hetionet:covaries:1616-23316Inferred only
LRR1 covaries with CUX2ProteinHetionet hetionet:covaries:122769-23316Inferred only
NFIA covaries with CUX2ProteinHetionet hetionet:covaries:23316-4774Inferred only
CUX2 covaries with SART3ProteinHetionet hetionet:covaries:23316-9733Inferred only
ZNF34 covaries with CUX2ProteinHetionet hetionet:covaries:23316-80778Inferred only
ZNF605 covaries with CUX2ProteinHetionet hetionet:covaries:100289635-23316Inferred only
CFTR interacts with CUX2ProteinHetionet hetionet:interacts:1080-23316Inferred only
CSNK2A1 interacts with CUX2ProteinHetionet hetionet:interacts:1457-23316Inferred only
HDAC1 interacts with CUX2ProteinHetionet hetionet:interacts:23316-3065Inferred only
CUX2 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology O14529|GO:0000122Inferred only

Show the remaining 6

CUX2 regulates positive regulation of dendrite morphogenesisBiological processgene ontology O14529|GO:0050775Inferred only
CUX2 regulates positive regulation of dendritic spine morphogenesisBiological processgene ontology O14529|GO:0061003Inferred only
CUX2 regulates positive regulation of excitatory postsynaptic potentialBiological processgene ontology O14529|GO:2000463Inferred only
CUX2 regulates positive regulation of gene expressionBiological processgene ontology O14529|GO:0010628Inferred only
CUX2 regulates positive regulation of synapse assemblyBiological processgene ontology O14529|GO:0051965Inferred only
CUX2 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology O14529|GO:0006357Inferred only

Other names

4 names

Resolves to: CUX2

Also called: CUTL2Homeobox protein cut-like 2Homeobox protein cux-2KIAA0293

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