Proteins/UNIPROT:Q96L50

LRR1

ProteinUNIPROT:Q96L50

Substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1..

Function from UniProtKB (Q96L50), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

17 statements

17 statements · 3 reference databases · Subject: LRR1 · Sources: gene ontology, Hetionet, Reactome

Order

LRR1 covaries with CUX2ProteinHetionet hetionet:covaries:122769-23316Inferred only
MYSM1 covaries with LRR1ProteinHetionet hetionet:covaries:114803-122769Inferred only
COPS5 interacts with LRR1ProteinHetionet hetionet:interacts:10987-122769Inferred only
COPS6 interacts with LRR1ProteinHetionet hetionet:interacts:10980-122769Inferred only
CUL2 interacts with LRR1ProteinHetionet hetionet:interacts:122769-8453Inferred only
CUL5 interacts with LRR1ProteinHetionet hetionet:interacts:122769-8065Inferred only
ELOC interacts with LRR1ProteinHetionet hetionet:interacts:122769-6921Inferred only
TNFRSF9 interacts with LRR1ProteinHetionet hetionet:interacts:122769-3604Inferred only
UBC interacts with LRR1ProteinHetionet hetionet:interacts:122769-7316Inferred only
LRR1 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
LRR1 participates in Antigen processing: Ubiquitination & Proteasome degradationPathwayReactome R-HSA-983168Inferred only
LRR1 participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only

Show the remaining 5

LRR1 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
LRR1 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
LRR1 participates in NeddylationPathwayReactome R-HSA-8951664Inferred only
LRR1 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
LRR1 regulates negative regulation of DNA-templated DNA replicationBiological processgene ontology Q96L50|GO:2000104Inferred only

Other names

6 names

Resolves to: LRR1

Also called: 4-1BB-mediated-signaling molecule4-1BBlrrLRR-1LRR-repeat protein 1Peptidylprolyl isomerase-like 5PPIL5

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