Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q12857

NFIA

Protein·UNIPROT:Q12857

Open in the graph

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Function from UniProtKB (Q12857), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

brain malformations with or without urinary tract defects has a germline basis in NFIADiseaseGenCC HGNC:7784|MONDO:0100478Inferred only
chromosome 1p32-p31 deletion syndrome has a germline basis in NFIADiseaseGenCC HGNC:7784|MONDO:0013396Inferred only

Statements

13 statements

13 statements · 4 reference databases · Subject: NFIA · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Search this listOrder

NFIA covaries with CUX2ProteinHetionet hetionet:covaries:23316-4774Inferred only
MEX3D covaries with NFIAProteinHetionet hetionet:covaries:399664-4774Inferred only
NFIA participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
NFIA participates in Mammary gland development pregnancy and lactation stage 3 of 4PathwayWikiPathways WP2817Inferred only
NFIA participates in miR targeted genes in lymphocytesPathwayWikiPathways WP2004Inferred only
NFIA participates in miR targeted genes in muscle cellPathwayWikiPathways WP2005Inferred only
NFIA participates in Oligodendrocyte developmentPathwayWikiPathways WP5574Inferred only
NFIA participates in RNA Polymerase III Abortive And Retractive InitiationPathwayReactome R-HSA-749476Inferred only
NFIA participates in RNA Polymerase III TranscriptionPathwayReactome R-HSA-74158Inferred only
NFIA participates in RNA Polymerase III Transcription TerminationPathwayReactome R-HSA-73980Inferred only
NFIA regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q12857|GO:0045944Inferred only
NFIA regulates regulation of DNA-templated transcriptionBiological processgene ontology Q12857|GO:0006355Inferred only

Show the remaining 1

NFIA regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q12857|GO:0006357Inferred only

Other names

9 names

Resolves to: NFIA

Also called: CCAAT-box-binding transcription factorCTFKIAA1439NF-I/ANF1-ANFI-ANuclear factor 1/ANuclear factor I/ATGGCA-binding protein

← Every protein Find it in the graph →