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Proteins/UNIPROT:Q9NRF8
CTP synthase involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides..
Function from UniProtKB (Q9NRF8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
20 statements
20 statements · 5 reference databases · Subject: CTPS2 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
ATP+ammonium+UTPADP+CHEBI:17677+proton+phosphate(3-)
Reaction pageLeft to rightBalancedEC 6.3.4.2cytosol
Human-GEM MAR04032CC BY 4.0Reference data
2 names
Resolves to: CTPS2
Reaction pageLeft to rightBalancedEC 6.3.4.2cytosol
Human-GEM MAR04194CC BY 4.0Reference data
UTP+L-glutamine+ATP(4-)+waterCTP+L-glutamate(1-)+ADP(3-)+hydrogenphosphate+2hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:26426CC BY 4.0Reference data