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Proteins/UNIPROT:Q14894
Catalyzes the NAD(P)H-dependent reduction of imine double bonds of a number of cyclic ketimine substrates, including sulfur-containing cyclic ketimines. Under physiological conditions, it efficiently catalyzes delta(1)-piperideine-2-carboxylate (P2C) and delta(1)-pyrroline-2-carboxylate (Pyr2C) reduction, suggesting a central role in lysine and glutamate metabolism. Additional substrates are delta(2)-thiazoline-2-carboxylate (T2C), 3,4-dehydrothiomorpholine-3-carboxylate (AECK), and (R)-lanthionine ketimine (LK) that is reduced at very low rate compared to other substrates. Also catalyzes the NAD(P)H-dependent reduction of (S)-cystathionine ketimine (CysK) (By similarity)..
Function from UniProtKB (Q14894), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
53 statements
53 statements · 6 reference databases · Subject: CRYM · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Reactome, Rhea
10 reactions
CHEBI:176873+NADP(3-)CHEBI:58517+NADPH(4-)+2hydron
Catalysed by CRYM
Reaction pageRight to leftBalanced
Rhea RHEA:12500CC BY 4.0Reference data
CHEBI:176873+NAD(1-)CHEBI:58517+NADH(2-)+2hydron
Catalysed by CRYM
Reaction pageRight to leftBalanced
4 names
Resolves to: CRYM
L-pipecolate+NADP(3-)CHEBI:77631+NADPH(4-)+hydron
Catalysed by CRYM
Reaction pageRight to leftBalanced
Rhea RHEA:12524CC BY 4.0Reference data
L-proline+NADP(3-)1-pyrroline-2-carboxylate+NADPH(4-)+hydron
Catalysed by CRYM
Reaction pageRight to leftBalanced
Rhea RHEA:20317CC BY 4.0Reference data
L-proline+NAD(1-)1-pyrroline-2-carboxylate+NADH(2-)+hydron
Catalysed by CRYM
Reaction pageRight to leftBalanced
Rhea RHEA:20321CC BY 4.0Reference data
L-pipecolate+NAD(1-)CHEBI:77631+NADH(2-)+hydron
Catalysed by CRYM
Reaction pageRight to leftBalanced
Rhea RHEA:30807CC BY 4.0Reference data
CHEBI:176808+NADH(2-)+2hydronCHEBI:176810+NAD(1-)
Catalysed by CRYM
Reaction pageLeft to rightBalanced
Rhea RHEA:68032CC BY 4.0Reference data
CHEBI:176808+NADPH(4-)+2hydronCHEBI:176810+NADP(3-)
Catalysed by CRYM
Reaction pageLeft to rightBalanced
Rhea RHEA:68036CC BY 4.0Reference data
CHEBI:176891+NADPH(4-)+2hydronCHEBI:176892+NADP(3-)
Catalysed by CRYM
Reaction pageLeft to rightBalanced
Rhea RHEA:68040CC BY 4.0Reference data
CHEBI:176895+NADPH(4-)+2hydronCHEBI:176896+NADP(3-)
Catalysed by CRYM
Reaction pageLeft to rightBalanced
Rhea RHEA:68072CC BY 4.0Reference data