Proteins/UNIPROT:P27658

COL8A1

ProteinUNIPROT:P27658

Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also a component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis..

Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis..

Function from UniProtKB (P27658), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

19 statements

19 statements · 2 reference databases · Subject: COL8A1 · Sources: Hetionet, Reactome

Order

DDX53 covaries with COL8A1ProteinHetionet hetionet:covaries:1295-168400Inferred only
COL8A1 covaries with FUOMProteinHetionet hetionet:covaries:1295-282969Inferred only
COL8A1 interacts with ADAMTSL4ProteinHetionet hetionet:interacts:1295-54507Inferred only
COL8A1 interacts with COL8A2ProteinHetionet hetionet:interacts:1295-1296Inferred only
COL8A1 interacts with EFEMP2ProteinHetionet hetionet:interacts:1295-30008Inferred only
COL8A1 interacts with FN1ProteinHetionet hetionet:interacts:1295-2335Inferred only
COL8A1 interacts with ITGA1ProteinHetionet hetionet:interacts:1295-3672Inferred only
COL8A1 interacts with ITGA2ProteinHetionet hetionet:interacts:1295-3673Inferred only
COL8A1 interacts with KLHL12ProteinHetionet hetionet:interacts:1295-59349Inferred only
COL8A1 interacts with KRTAP4-12ProteinHetionet hetionet:interacts:1295-83755Inferred only
COL8A1 interacts with UBQLN4ProteinHetionet hetionet:interacts:1295-56893Inferred only
COL8A1 participates in Assembly of collagen fibrils and other multimeric structuresPathwayReactome R-HSA-2022090Inferred only

Show the remaining 7

COL8A1 participates in Collagen biosynthesis and modifying enzymesPathwayReactome R-HSA-1650814Inferred only
COL8A1 participates in Collagen chain trimerizationPathwayReactome R-HSA-8948216Inferred only
COL8A1 participates in Collagen degradationPathwayReactome R-HSA-1442490Inferred only
COL8A1 participates in Collagen formationPathwayReactome R-HSA-1474290Inferred only
COL8A1 participates in Degradation of the extracellular matrixPathwayReactome R-HSA-1474228Inferred only
COL8A1 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
COL8A1 participates in Integrin cell surface interactionsPathwayReactome R-HSA-216083Inferred only

Other names

4 names

Resolves to: COL8A1

Also called: C3orf7chainEndothelial collagenVIII

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